Transformations of thiopyrimidine and thiopurine nucleosides following oxidation with dimethyldioxirane.

被引：29

作者：

Saladino, R

Mincione, E

Crestini, C

Mezzetti, M

机构：

[1] Dipto. Agrochimico Agrobiologico, Univ. Studi di Viterbo La Tuscia, 01100 Viterbo, via San Camillo de Lellis

来源：

TETRAHEDRON | 1996年 / 52卷 / 19期

关键词：

D O I：

10.1016/0040-4020(96)00289-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and convenient method for the synthesis of several pyrimidine and purine nucleosides by selective oxidation of thionucleosides with dimethyldioxirane is reported. Thioketo moieties in the C-4 position of the pyrimidine ring, and in the C-6, and C-8 positions of the purine ring are the domain of oxidative nucleophilic substitution. Thioketo moieties in the C-2 position of both purine and pyrimidine rings are the domain of desulfurization or formation of disulfides. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：6759 / 6780

页数：22

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