The Plasmodium falciparum translationally controlled tumor protein:: subcellular localisation and calcium binding

被引:30
作者
Bhisutthibhan, J
Philbert, MA
Fujioka, H
Aikawa, M
Meshnick, SR [1 ]
机构
[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Publ Hlth, Dept Environm & Ind Hlth, Ann Arbor, MI 48109 USA
[3] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA
[4] Tokai Univ, Res Inst Med Sci, Kanegawa, Japan
关键词
malaria; antimalarial; qinghaosu; immunofluorescence; immunoelectron microscopy;
D O I
10.1016/S0171-9335(99)80052-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Artemisinin derivatives are endoperoxide antimalarials widely used to treat falciparum malaria in areas where drug resistance is common. In Plasmodium falciparum-infected erythrocytes, radiolabeled artemisinin derivatives have been shown to react with malarial proteins, one of which is the Translationally Controlled Tumor Protein (TCTP). The P. falciparum TCTP was found by immunofluorescence to be located in both the cytoplasm and food vacuoles. Immunoelectron microscopy shows that it is present in the parasite cytoplasm as well as in its food vacuolar and limiting membranes. Like other TCTPs, the P. falciparum protein binds to calcium. Further studies on the physiological role of TCTP may aid in understanding the mechanism of action of endoperoxide antimalarials.
引用
收藏
页码:665 / 670
页数:6
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