Newly described pattern recognition receptors team up against intracellular pathogens

被引：403

作者：

Broz, Petr ^{[1
]}

Monack, Denise M. ^{[2
]}

机构：

[1] Univ Basel, Focal Area Infect Biol, Biozentrum, CH-4056 Basel, Switzerland

[2] Stanford Univ, Stanford Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 08期

基金：

瑞士国家科学基金会;

关键词：

CYCLIC DI-GMP; TOLL-LIKE RECEPTORS; INNATE IMMUNE RECOGNITION; CYTOSOLIC DNA SENSOR; RIG-I; INFLAMMASOME ACTIVATION; CUTTING EDGE; RNA HELICASE; CELL-DEATH; BACTERIAL FLAGELLIN;

D O I：

10.1038/nri3479

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Recognizing the presence of invading pathogens is key to mounting an effective innate immune response. Mammalian cells express different classes of germline-encoded pattern recognition receptors that monitor the extracellular and intracellular compartments of host cells for signs of infection and that activate several conserved signalling pathways. An efficient immune response often requires the sequential detection of a pathogen by different receptors in different subcellular compartments, which results in a complex interplay of downstream signalling pathways. In this Review, we discuss the recent identification of previously unknown pattern recognition receptors and how they complement the repertoire of established receptors.

引用

页码：551 / 565

页数：15

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