Iron-phosphine, -phosphite, -arsine, and -carbene catalysts for the coupling of primary and secondary 2 alkyl halides with aryl Grignard reagents

被引：245

作者：

Bedford, RB

Betham, M

Bruce, DW

Danopoulos, AA

Frost, RM

Hird, M

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[3] Univ Exeter, Dept Chem, Exeter EX4 4QD, Devon, England

[4] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

[5] Univ Hull, Kingston Upon Hull HU6 7RX, N Humberside, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 03期

关键词：

D O I：

10.1021/jo052250+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[graphics] Simple catalysts formed in situ from iron chloride and a wide range of monodentate and bidentate phosphines and arsines have been screened in the coupling of alkyl halides bearing beta-hydrogens with aryl Grignard reagents. The best of these show excellent activity, as do catalysts formed in situ with monodentate trialkyl and triaryl phosphite ligands. N-heterocyclic carbene-based precatalysts, either preformed or made in situ, also show excellent performance.

引用

页码：1104 / 1110

页数：7

共 32 条

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