Harnessing the Power of the Immune System to Target Cancer

被引：114

作者：

Lizee, Gregory ^{[1
]}

Overwijk, Willem W. ^{[1
]}

Radvanyi, Laszlo ^{[1
]}

Gao, Jianjun ^{[2
]}

Sharma, Padmanee ^{[2
]}

Hwu, Patrick ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Ctr Canc Immunol Res, Dept Melanoma Med Oncol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA

来源：

ANNUAL REVIEW OF MEDICINE, VOL 64 | 2013年 / 64卷

关键词：

immunotherapy; vaccines; T cells; adoptive transfer; immune checkpoint blockade; BASAL-CELL-CARCINOMA; TUMOR-INFILTRATING LYMPHOCYTES; IMIQUIMOD 5-PERCENT CREAM; IN-SITU VACCINATION; METASTATIC MELANOMA; PHASE-I; T-CELLS; CLINICAL ACTIVITY; ADOPTIVE TRANSFER; RANDOMIZED-TRIAL;

D O I：

10.1146/annurev-med-112311-083918

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

For many years, immunotherapeutic approaches for cancer held more promise than actual clinical benefit for the majority of patients. However, several recent key advances in tumor immunology have now turned the tide in favor of immunotherapy for the treatment of many different cancer types. In this review, we describe four of the most effective immunotherapeutic approaches currently used in the clinic: cancer vaccines, immunostimulatory agents, adoptive T cell therapy, and immune checkpoint blockade. In addition, we discuss some of the most promising future strategies that aim to utilize multiple immunotherapies or combine them with other approaches to more effectively target cancer.

引用

页码：71 / 90

页数：20

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