Neurovascular development and links to disease

被引：66

作者：

Ruhrberg, Christiana ^{[1
]}

Bautch, Victoria L. ^{[2
,3
,4
]}

机构：

[1] UCL, UCL Inst Ophthalmol, London EC1V 9EL, England

[2] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, McAllister Heart Inst, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2013年 / 70卷 / 10期

基金：

英国惠康基金;

关键词：

Neurovascular; Neural tube; Retina; Hindbrain; VEGF; Semaphorins; Neuropilin; GPCR124; TGF beta; ENDOTHELIAL GROWTH-FACTOR; BLOOD-BRAIN-BARRIER; PROTEIN-COUPLED RECEPTOR; CENTRAL-NERVOUS-SYSTEM; STEM-LIKE CELLS; VEGF-A; VASCULAR DEVELOPMENT; VESSEL FORMATION; RHOMBOMERE BOUNDARIES; RETINAL VASCULATURE;

D O I：

10.1007/s00018-013-1277-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The developing central nervous system (CNS) is vascularized via ingression of blood vessels from the outside as the neural tissue expands. This angiogenic process occurs without perturbing CNS architecture due to exquisite cross-talk between the neural compartment and invading blood vessels. Subsequently, this intimate relationship also promotes the formation of the neurovascular unit that underlies the blood-brain barrier and regulates blood flow to match brain activity. This review provides a historical perspective on research into CNS blood vessel growth and patterning, discusses current models used to study CNS angiogenesis, and provides an overview of the cellular and molecular mechanisms that promote blood vessel growth and maturation. Finally, we highlight the significance of these mechanisms for two different types of neurovascular CNS disease.

引用

页码：1675 / 1684

页数：10

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