Towards understanding the aetiology and pathophysiology of the emetic reflex: Novel approaches to antiemetic drugs

被引：26

作者：

Bountra, C ^{[1
]}

Gale, JD ^{[1
]}

Gardner, CJ ^{[1
]}

Jordan, CC ^{[1
]}

Kilpatrick, GJ ^{[1
]}

Twissell, DJ ^{[1
]}

Ward, P ^{[1
]}

机构：

[1] GLAXO RES & DEV LTD,DIV CHEM,EMESIS RES GRP,WARE SG12 0DP,HERTS,ENGLAND

来源：

ONCOLOGY | 1996年 / 53卷

关键词：

emesis; antiemetic; neurokinin antagonist;

D O I：

10.1159/000227649

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The introduction of 5-HT3 antagonists, such as ondansetron, as antiemetic agents has transformed the management of patients receiving chemotherapy or radiation therapy. Studies in animal models with NK1 antagonists suggest that these represent a new class of antiemetic agents having a broader spectrum of activity than 5-HT3 antagonists. Compounds of this class may prove to be more effective in man against delayed emesis induced by cisplatin, postoperative nausea and vomiting and motion sickness. Thus, they have the potential to complement 5-HT3 antagonists and so provide a further advance in the management of nausea and vomiting.

引用

页码：102 / 109

页数：8

共 17 条

[1]

BAUDE A, 1989, J CHEM NEUROANAT, V2, P67

[2] ANTIEMETIC PROFILE OF A NONPEPTIDE NEUROKININ-NK(1) RECEPTOR ANTAGONIST, CP-99,994, IN FERRETS [J].

BOUNTRA, C ;

BUNCE, K ;

DALE, T ;

GARDNER, C ;

JORDAN, C ;

TWISSELL, D ;

WARD, P .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 249 (01) :R3-R4

[3]

BROWN GW, 1992, ONCOLOGY, V49, P273

[4]

BUNCE KT, 1992, BR J ANAESTH S1, V69, P605

[5] EMESIS INDUCED BY CISPLATIN IN THE FERRET AS A MODEL FOR THE DETECTION OF ANTIEMETIC DRUGS [J].

COSTALL, B ;

DOMENEY, AM ;

NAYLOR, RJ ;

TATTERSALL, FD .

NEUROPHARMACOLOGY, 1987, 26 (09) :1321-1326

[6] PREVENTION OF EMESIS IN PATIENTS RECEIVING CYTOTOXIC DRUGS BY GR38032F, A SELECTIVE 5-HT3 RECEPTOR ANTAGONIST [J].

CUNNINGHAM, D ;

POPLE, A ;

FORD, HT ;

HAWTHORN, J ;

GAZET, JC ;

CHALLONER, T ;

COOMBES, RC .

LANCET, 1987, 1 (8548) :1461-1463

[7] NEUROGENIC INFLAMMATION [J].

FOREMAN, JC ;

JORDAN, CC .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1984, 5 (03) :116-119

[8]

Gardner C. J., 1994, British Journal of Pharmacology, V112, p516P

[9]

HAGAN RM, 1991, BRIT J PHARMACOL, V102, pP168

[10]

KOCH KL, 1993, GASTROENTEROLOGY, V104, pA535

← 1 2 →