Preparation and immunological activity of polysaccharides and their derivatives

被引：226

作者：

Chen, Fang ^{[1
]}

Huang, Gangliang ^{[1
]}

机构：

[1] Chongqing Normal Univ, Coll Chem, Act Carbohydrate Res Ctr, Chongqing 401331, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 112卷

关键词：

Polysaccharides; Chemical modification; Immunological activity; WEANED PIGLETS; IN-VITRO; DERIVATIZATION; LYMPHOCYTES; MACROPHAGES; ACTIVATION; CYTOKINES; CELLS;

D O I：

10.1016/j.ijbiomac.2018.01.169

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Polysaccharide is a kind of natural macromolecule polymer, which is widely existed in animals, plants and microorganisms, has a variety of biological activities, such as anti-tumor, anti-virus, anti-oxidation and immune regulation. Polysaccharides can affect macrophages, cells and other immune cells to improve the body's immune function, and have no toxic and side effects on normal cells, which make the polysaccharides receive widespread attention. In recent years, studies have shown that structural modification of polysaccharides can improve the immunological activity of polysaccharides. The common chemical modifications are sulfation, carboxymethylation, acetylation, phosphorylation, and so on. The chemical modification of polysaccharides and the immunomodulation of polysaccharides and polysaccharide derivatives were analyzed and discussed. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：211 / 216

页数：6

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