Identification of potent and selective oxytocin antagonists. Part 2: Further investigation of benzofuran derivatives

被引：46

作者：

Wyatt, PG

Allen, MJ

Chilcott, J

Gardner, CJ

Livermore, DG

Mordaunt, JE

Nerozzi, F

Patel, M

Perren, MJ

Weingarten, GG

Shabbir, S

Woollard, PM

Zhou, P

机构：

[1] GlaxoSmithKline, Med Res Ctr, Dept Med Chem, Stevenage SG1 2NY, Herts, England

[2] GlaxoSmithKline, Med Res Ctr, Dept Receptor Pharmacol, Stevenage SG1 2NY, Herts, England

[3] GlaxoSmithKline, Med Res Ctr, Dept Res Biometab, Stevenage SG1 2NY, Herts, England

[4] GlaxoSmithKline, Neurol Ctr Excellence Drug Discovery, Harlow CM19 5AW, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(02)00160-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The paper covers continuing efforts to discover novel, potent and selective oxytocin antagonists. Further benzofuran derivatives with potent oxytocin antagonist activity and good pharmacokinetic parameters are reported. Efforts to improve the in vivo activity of the series are described. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：1405 / 1411

页数：7

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