Synthesis and properties of a novel water-soluble anionic polyfluorenes for highly sensitive biosensors

被引：74

作者：

Huang, F

Wang, XH

Wang, DL ^{[1
]}

Yang, W

Cao, Y

机构：

[1] Univ Calif San Diego, Dept Elect & Comp Engn, La Jolla, CA 92093 USA

[2] S China Univ Technol, Key Lab Specially funct Mat & Adv Mfg Technol, Inst Polymer Optoelect Mat & Devices, Guangzhou 510640, Peoples R China

来源：

POLYMER | 2005年 / 46卷 / 25期

基金：

中国国家自然科学基金;

关键词：

polyelectrolyte; water-soluble; biosensor;

D O I：

10.1016/j.polymer.2005.10.034

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A new anionic water-soluble polyfluorene-poly(9,9-bis(4 '-sulfonatobutyl)fluorene-co-alt-1,4-phenylene) sodium salt (PFS) was synthesized by Suzuki-coupling reaction. The anionic polyfluorene shows bright blue photoluminescence and it Was found the photoluminescence could be highly quenched by a bioactive dye (Lucifer yellow cadaverine biotin-X dipotassium salt). PFS photoluminescence quenching only occurs effectively upon addition of avidin. The photoluminescence quenching process is sensitive to even subnanomolar amount of avidin (10(-10) M). The avidin facilitated photoluminescence quenching opens up opportunities of new Ultra-high efficiency and rapid response biosensors based on the polyfluorene electrolyte. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：12010 / 12015

页数：6

共 22 条

[1]

Baur JW, 1998, ADV MATER, V10, P1452, DOI 10.1002/(SICI)1521-4095(199812)10:17<1452::AID-ADMA1452>3.0.CO

[2]

2-V

[3] Highly sensitive biological and chemical sensors based on reversible fluorescence quenching in a conjugated polymer [J].