Telomere length of normal leukocytes is affected by a functional polymorphism of hTERT

被引：73

作者：

Matsubara, Y ^{[1
]}

Murata, M

Yoshida, T

Watanabe, K

Saito, I

Miyaki, K

Omae, K

Ikeda, Y

机构：

[1] Keio Univ, Sch Med, Dept Internal Med, Tokyo 108, Japan

[2] Keio Univ, Sch Med, Dept Lab Med, Tokyo 108, Japan

[3] Hoshi Univ, Fac Pharmacol, Dept Pathophysiol, Tokyo 142, Japan

[4] Keio Univ, Ctr Hlth, Tokyo 108, Japan

[5] Keio Univ, Sch Med, Dept Prevent Med & Publ Hlth, Tokyo 108, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 341卷 / 01期

关键词：

human telomerase reverse transcriptase; polymorphism; telomere length;

D O I：

10.1016/j.bbrc.2005.12.163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Transcriptional regulation of human telomerase reverse transcriptase (hTERT), a catalytic subunit of telomerase, is essential for telomerase activity associated with telomere length. In this study, we investigated the effects of a T-1327/C polymorphism within the hTERT promoter region on the hTERT promoter activity and leukocyte telomere length in normal individuals. The promoter activity in the T-1327-sequence was significantly higher than that in the C-1327-sequence (p = 0.0004). For leukocyte telomere length, the T-1327-allele carriers had significantly longer than the T-1327-allele non-carriers (p = 0.0007). Also, there was no age-related shortening in leukocyte telomere length in the T-1327/T (p = 0.6633) and T-1327/C subjects (p = 0.1691), whereas there was clear age-related telomere shortening in the C-1327/C subjects (p = 0.0117). These findings suggest that the functional T-1327/C polymorphism of hTERT is associated with leukocyte telomere length in normal individuals. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：128 / 131

页数：4

共 23 条

[1]

Telomere length as an indicator of biological aging - The gender effect and relation with pulse pressure and pulse wave velocity [J].