GPCR modulation by RAMPS

被引:195
作者
Hay, DL
Poyner, DR
Sexton, PM
机构
[1] Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Carlton, Vic 3053, Australia
[2] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England
[3] Univ Auckland, Sch Biol Sci, Auckland 1, New Zealand
基金
英国生物技术与生命科学研究理事会;
关键词
calcitonin receptor; CL receptor; family B GPCR; GPCR; RAMP; VPAC1; receptor;
D O I
10.1016/j.pharmthera.2005.06.015
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Our conceptual understanding of the molecular architecture of G-protein coupled receptors (GPCRs) has transformed over the last decade. Once considered as largely independent functional units (aside from their interaction with the G-protein itself), it is now clear that a single GPCR is but part of a multifaceted signaling complex, each component providing an additional layer of sophistication. Receptor activity-modifying proteins (RAMPs) provide a notable example of proteins that interact with GPCRs to modify their function. They act as pharmacological switches, modifying GPCR pharmacology for a particular subset of receptors. However, there is accumulating evidence that these ubiquitous proteins have a broader role, regulating signaling and receptor trafficking. This article aims to provide the reader with a comprehensive appraisal of RAMP literature and perhaps some insight into the impact that their discovery has had on those who study GPCRs. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:173 / 197
页数:25
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