Serotonin and hippocampal neurogenesis

被引：151

作者：

Gould, E ^{[1
]}

机构：

[1] Princeton Univ, Dept Psychol, Princeton, NJ 08544 USA

来源：

NEUROPSYCHOPHARMACOLOGY | 1999年 / 21卷 / 02期

关键词：

neurogenesis; 5HT1A receptor; dentate gyrus; hippocampus; granule cell; stress;

D O I：

10.1016/S0893-133X(99)00045-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The dentate gyrus continues to produce near granule neurons well into adulthood. This has been demonstrated for many mammalian species, from rodents to primates. The proliferation of granule cell precursors can be suppressed by stressful experiences, presumably via adrenal steroids. Recent evidence suggests that serotonin can enhance the production of new neurons via activation of the 5HT1A receptor. These results present the possibility that the inhibitory effects of stress on granule cell production may be prevented by 5HT1A receptor agonists. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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页码：S46 / S51

页数：6

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