Osteoinductive growth factors in preclinical fracture and long bone defects models

被引：85

作者：

Bostrom, MPG

Saleh, KJ

Einhorn, TA

机构：

[1] Hosp Special Surg, New York, NY 10021 USA

[2] Boston Univ, Sch Med, Boston Med Ctr, Dept Orthopaed Surg, Boston, MA 02118 USA

[3] Univ Minnesota, Dept Orthopaed Surg, Minneapolis, MN 55455 USA

来源：

ORTHOPEDIC CLINICS OF NORTH AMERICA | 1999年 / 30卷 / 04期

关键词：

D O I：

10.1016/S0030-5898(05)70117-6

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Fracture healing is a specialized form of the reparative process that the musculoskeletal system undergoes to restore skeletal integrity. This biologic process is a consequence of a complex cascade of biologic events that result in the restoration of bone tissue, allowing for the resumption of musculoskeletal function. Several growth-promoting substances have been identified at the site of skeletal injury and appear to play a physiologic role in fracture healing. This article reviews the effects of these osteoinductive growth factors on bone healing as elucidated by both preclinical in vivo fracture and diaphyseal defect healing models.

引用

页码：647 / +

页数：13

共 58 条

[1] DOSE-RESPONSE OF GROWTH-HORMONE ON FRACTURE-HEALING IN THE RAT
BAK, B
JORGENSEN, PH
ANDREASSEN, TT
[J]. ACTA ORTHOPAEDICA SCANDINAVICA, 1990, 61 (01): : 54 - 57
[2] INCREASED MECHANICAL STRENGTH OF HEALING RAT TIBIAL FRACTURES TREATED WITH BIOSYNTHETIC HUMAN GROWTH-HORMONE
BAK, B
JORGENSEN, PH
ANDREASSEN, TT
[J]. BONE, 1990, 11 (04) : 233 - 239
[3] BECK LS, 1991, J BONE MINER RES, V6, P1257
[4] BECK LS, 1996, T ORTHOP RES SOC, V21, P626
[5] BECK LS, 1995, T ORTHOP RES SOC, V20, P593
[6] Exogenous fibroblast growth factors-1 and -2 do not accelerate fracture healing in the rabbit
Bland, YS
Critchlow, MA
Ashhurst, DE
[J]. ACTA ORTHOPAEDICA SCANDINAVICA, 1995, 66 (06): : 543 - 548
[7] BOLANDER ME, 1992, P SOC EXP BIOL MED, V200, P165
[8] Use of bone morphogenetic protein-2 in the rabbit ulnar nonunion model
Bostrom, M
Lane, JM
Tomin, E
Browne, M
Berberian, W
Turek, T
Smith, J
Wozney, J
Schildhauer, T
[J]. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 1996, (327) : 272 - 282
[9] Bostrom MP, 1998, CLIN ORTHOP S, V355s, P274
[10] IMMUNOLOCALIZATION AND EXPRESSION OF BONE MORPHOGENETIC PROTEIN-2 AND PROTEIN-4 IN FRACTURE-HEALING
BOSTROM, MPG
LANE, JM
BERBERIAN, WS
MISSRI, AAE
TOMIN, E
WEILAND, A
DOTY, SB
GLASER, D
ROSEN, VM
[J]. JOURNAL OF ORTHOPAEDIC RESEARCH, 1995, 13 (03) : 357 - 367

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