Does the cell number 109 still really fit one gram of tumor tissue?

被引：248

作者：

Del Monte, Ugo ^{[1
]}

机构：

[1] Univ Milan, Inst Gen Pathol, I-20133 Milan, Italy

来源：

CELL CYCLE | 2009年 / 8卷 / 03期

关键词：

tumor growth kinetics; cell packings; cells per unit of tumor tissue; clinically detectable tumors; tumor metastatic inefficiency;

D O I：

10.4161/cc.8.3.7608

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A tumor reaching the size of 1 cm(3) ( approximately 1 g wet weight) is commonly assumed to contain 1 x 109 cells. This paper comments on the probable origin of this "magic" number and on some possible reasons why it has remained in use until now. However, mostly in epithelial tumors (85% of all human tumors) a cell number one order of magnitude smaller would be more realistic.

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页码：505 / 506

页数：2

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