Superoxide dismutase mimetic complex of Mn(II)/N,N-bis(2-pyridylmethyl)-(S)-histidine

被引：13

作者：

Yamato, K

Miyahara, I

Ichimura, A

Hirotsu, K

Kojima, Y ^{[1
]}

Sakurai, H

Shiomi, D

Sato, K

Takui, T

机构：

[1] Osaka City Univ, Grad Sch Sci, Dept Chem, Sumiyoshi Ku, Osaka 5588585, Japan

[2] Osaka City Univ, Grad Sch Sci, Dept Mat Sci, Sumiyoshi Ku, Osaka 5588585, Japan

[3] Kyoto Pharmaceut Univ, Dept Analyt & Bioorgan Chem, Yamashina Ku, Kyoto 6078414, Japan

来源：

CHEMISTRY LETTERS | 1999年 / 04期

关键词：

D O I：

10.1246/cl.1999.295

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel dinuclear Mn(II) complex, [Mn(L)(H2O)](2)(ClO4)(2) (1) where L is N, N-bis(2-pyridylmethyl)-(S)-histidinate, was synthesized. X-ray structure analysis of 1 revealed that each Mn(II) ion is a doubly carboxylate-bridged sevencoordinate structure. Cyclic voltammmetry indicated that electrode reaction of 1 was dependent on pH, The reactivity toward superoxide was evaluated by in vitro xanthine-xanthine oxidase-cytochrome c assay. The IC50 value of 1 is equal to 0.29 mu M (1 M = 1 mol dm(-3)), which is one of the highest values in Mn(II) SOD mimetic complexes.

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页码：295 / 296

页数：2

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