Single step synthesis and characterization of thermoresponsive hyaluronan hydrogels

被引：74

作者：

D'Este, Matteo ^{[1
]}

Alini, Mauro ^{[1
]}

Eglin, David ^{[1
]}

机构：

[1] AO Res Inst Davos, CH-7270 Davos, Switzerland

来源：

CARBOHYDRATE POLYMERS | 2012年 / 90卷 / 03期

关键词：

Hyaluronan; Poly(N-isopropylacrylamide); Stimuli responsive hydrogel; DRUG-RELEASE; DEGRADATION; COPOLYMERS; ACID; POLY(N-ISOPROPYLACRYLAMIDE); PULLULAN;

D O I：

10.1016/j.carbpol.2012.07.007

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

An efficient and scale-up ready single-step synthesis for the conjugation of thermoresponsive polymers to hyaluronic acid (HA) was established. Jeffamines (R) (JFM) and poly(N-isopropylacrylamide) (PNIPAM) were grafted to HA via direct amidation mediated by 1,1'-carbonyldiimidazole activation. The temperature-induced gelation of the semi-synthetic co-polymers was characterized by rheology as a function of the temperature and by differential scanning calorimetry (DSC). A HA-JFM conjugate with sol-gel transition in a physiologically relevant temperature range was identified. The grafting of PNIPAM resulted in the drastic change of the main rheological properties of native HA, revealing the hydrophobic non-covalent nature of the interactions between the thermoresponsive brushes in the gel state. Owing to the reversibility of these interactions and the sharpness of the transition, the HA-PNIPAM conjugates are suitable candidates for the incorporation of drugs, cells or ceramic materials for different biomedical applications. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1378 / 1385

页数：8

共 28 条

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