A recombinant Yellow Fever 17D vaccine expressing Lassa virus glycoproteins

被引：79

作者：

Bredenbeek, PJ

Molenkamp, R

Spaan, WJM

Deubel, V

Marianneau, P

Salvato, MS

Moshkoff, D

Zapata, J

Tikhonov, C

Patterson, J

Carrion, R

Ticer, A

Brasky, K

Lukashevich, IS ^{[1
]}

机构：

[1] Univ Maryland, Inst Biotechnol, Inst Human Virol, 725 W Lombard St, Baltimore, MD 21201 USA

[2] SW Fdn Biomed Res, Dept Virol & Immunol, San Antonio, TX 78245 USA

[3] Leiden Univ, Med Ctr, Ctr Infect Dis, Dept Med Microbiol, Leiden, Netherlands

[4] Ctr Rech Meriuex Pasteur Lyon, Unite Biol Infect Emergentes, Lab Jean Merieux P4, Lyon, France

来源：

VIROLOGY | 2006年 / 345卷 / 02期

关键词：

yellow and lassa fevers; YFV17D vaccine; recombinant vaccine;

D O I：

10.1016/j.virol.2005.12.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Yellow Fever Vaccine 17D (YFV17D) has been used as a vector for the Lassa virus glycoprotein precursor (LASV-GPC) resulting ill construction of YFV17D/LASV-GPC recombinant Virus. The virus was replication-competent and processed the LASV-GPC ill Cell Cultures. The recombinant replicated poorly in guinea pigs but Still elicited specific antibodies against LASV and YFV17D antigens. A single subcutaneous injection of the recombinant vaccine protected strain 13 guinea pigs against fatal Lassa Fever. This Study demonstrates the potential to develop an YFV17D-based bivalent vaccine against two viruses that are endemic in the same area of Africa. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：299 / 304

页数：6

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