Mechanisms of Acute Coronary Syndromes and Their Implications for Therapy

被引：1006

作者：

Libby, Peter ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc Med,Dept Med, Boston, MA 02115 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2013年 / 368卷 / 21期

关键词：

PROMOTES COLLAGEN ACCUMULATION; OPTICAL COHERENCE TOMOGRAPHY; TISSUE FACTOR EXPRESSION; FIBROUS-CAP THICKNESS; ATHEROSCLEROTIC PLAQUES; MYOCARDIAL-INFARCTION; MATRIX METALLOPROTEINASES; CARDIOVASCULAR EVENTS; MONOCLONAL-ANTIBODY; CULPRIT LESIONS;

D O I：

10.1056/NEJMra1216063

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Our understanding of the pathogenesis of acute coronary syndromes has undergone a veritable revolution in the past 20 years. We now understand in molecular and cellular terms how most serious thrombotic complications of coronary atherosclerosis occur. In particular, inflammatory pathways have emerged as important drivers of plaque disruption and thrombosis. This insight into the pathophysiological features of acute coronary syndromes expands the scope of treatment of this disease beyond the traditional focus on reducing stenoses. The laboratory and clinical data summarized here should help us both to understand how contemporary therapies can reduce the risk of these events and to make further inroads against the residual burden of disease in the future. Copyright © 2013 Massachusetts Medical Society. All rights reserved.

引用

页码：2004 / 2013

页数：10

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