Mapping in pig of genes involved in sexual differentiation: AMH, WT1, FTZF1, SOX2, SOX9, AHC, and placental and embryonic CYP19

被引：28

作者：

LahbibMansais, Y ^{[1
]}

Barbosa, A ^{[1
]}

Yerle, M ^{[1
]}

Parma, P ^{[1
]}

Milan, D ^{[1
]}

Pailhoux, E ^{[1
]}

Gellin, J ^{[1
]}

Cotinot, C ^{[1
]}

机构：

[1] INRA,BIOL CELLULAIRE & MOL LAB,JOUY EN JOSAS,FRANCE

来源：

CYTOGENETICS AND CELL GENETICS | 1997年 / 76卷 / 1-2期

关键词：

D O I：

10.1159/000134525

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Intersexuality has been reported in pigs and investigations are in progress to identify and physically map the genes involved in sex-reversal. In this study we have mapped on porcine chromosomes seven genes which might be implicated in this developmental pathway. Four genes were mapped by radioactive in situ hybridization: AMH (Anti-Mullerian Hormone) and WT1 (Wilms' Tumor gene 1) were both mapped to pig chromosome 2 (SSC2) in the q14 --> q21 and p14 --> q11 regions, placental CYP19 (cytochrome P450, subfamily XIX) and FTZF1 (fushi tarazu factor [Drosophila] homolog 1, alias SF1 [steroidogenic factor 1]) to pig chromosome 1 (SSC1) in the q14 --> q17 and q210 --> q211 regions respectively. Four other genes were regionally located by PCR analysis on a cytogenetically characterized porcine somatic cell hybrid panel: a second CYP19 gene (expressed in embryo) was mapped to porcine 1q12 --> q17, AHC (alias DAX1, adrenal hypoplasia congenital) to porcine Xp24, SOX2 and SOX9 (SRY sex determining region Y-box 2 and 9) to 13q23 --> q41 and 12p13 --> p11 respectively. These results are in global agreement with mapping data available in other mammalian species.

引用

页码：109 / 114

页数：6

共 39 条

[1] THE PIGMAP CONSORTIUM LINKAGE MAP OF THE PIG (SUS SCROFA) [J].

ARCHIBALD, AL ;

HALEY, CS ;

BROWN, JF ;

COUPERWHITE, S ;

MCQUEEN, HA ;

NICHOLSON, D ;

COPPIETERS, W ;

VANDEWEGHE, A ;

STRATIL, A ;

WINTERO, AK ;

FREDHOLM, M ;

LARSEN, NJ ;

NIELSEN, VH ;

MILAN, D ;

WOLOSZYN, N ;

ROBIC, A ;

DALENS, M ;

RIQUET, J ;

GELLIN, J ;

CARITEZ, JC ;

BURGAUD, G ;

OLLIVIER, L ;

BIDANEL, JP ;

VAIMAN, M ;

RENARD, C ;

GELDERMANN, H ;

DAVOLI, R ;

RUYTER, D ;

VERSTEGE, EJM ;

GROENEN, MAM ;

DAVIES, W ;

HOYHEIM, B ;

KEISERUD, A ;

ANDERSSON, L ;

ELLEGREN, H ;

JOHANSSON, M ;

MARKLUND, L ;

MILLER, JR ;

DEAR, DVA ;

SIGNER, E ;

JEFFREYS, AJ ;

MORAN, C ;

LETISSIER, P ;

MULADNO ;

ROTHSCHILD, MF ;

TUGGLE, CK ;

VASKE, D ;

HELM, J ;

LIU, HC ;

RAHMAN, A .

MAMMALIAN GENOME, 1995, 6 (03) :157-175

[2] ASSIGNMENT OF THE TENASCIN GENE (HXB) TO SWINE CHROMOSOME 1Q21.1-]Q21.3 BY FLUORESCENCE IN-SITU HYBRIDIZATION [J].

AWATA, T ;

YAMAKUCHI, H ;

KUMAGAI, M ;

YASUE, H .

CYTOGENETICS AND CELL GENETICS, 1995, 69 (1-2) :33-34

[3]

CHEVALET C, 1997, IN PRESS CABIOS

[4] Molecular cloning of cytochrome P450 aromatase complementary deoxyribonucleic acid from periimplantation porcine and equine blastocysts identifies multiple novel 5'-untranslated exons expressed in embryos, endometrium, and placenta [J].

Choi, IH ;

Simmen, RCM ;

Simmen, FA .

ENDOCRINOLOGY, 1996, 137 (04) :1457-1467

[5] FUNCTIONAL OVARIAN AND PLACENTAL ISOFORMS OF PORCINE AROMATASE [J].

CORBIN, CJ ;

KHALIL, MW ;

CONLEY, AJ .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1995, 113 (01) :29-37

[6] A PHYSICALLY ANCHORED LINKAGE MAP OF PIG CHROMOSOME-1 UNCOVERS SEX-SPECIFIC AND POSITION-SPECIFIC RECOMBINATION RATES [J].

ELLEGREN, H ;

CHOWDHARY, BP ;

FREDHOLM, M ;

HOYHEIM, B ;

JOHANSSON, M ;

NIELSEN, PB ;

THOMSEN, PD ;

ANDERSSON, L .

GENOMICS, 1994, 24 (02) :342-350

[7] CAMPOMELIC DYSPLASIA AND AUTOSOMAL SEX REVERSAL CAUSED BY MUTATIONS IN AN SRY-RELATED GENE [J].

FOSTER, JW ;

DOMINGUEZSTEGLICH, MA ;

GUIOLI, S ;

KWOK, C ;

WELLER, PA ;

STEVANOVIC, M ;

WEISSENBACH, J ;

MANSOUR, S ;

YOUNG, ID ;

GOODFELLOW, PN ;

BROOK, JD ;

SCHAFER, AJ .

NATURE, 1994, 372 (6506) :525-530

[8] THE BOVINE GENOME MAP [J].

FRIES, R ;

EGGEN, A ;

WOMACK, JE .

MAMMALIAN GENOME, 1993, 4 (08) :405-428

[9] LOCALIZATION OF THE TENASCIN-C GENE TO PIG CHROMOSOME-1 [J].

GARRIDO, JJ ;

LAHBIBMANSAIS, Y ;

GEFFROTIN, C ;

YERLE, M ;

VAIMAN, M .

MAMMALIAN GENOME, 1995, 6 (03) :221-221

[10] THE GENOMIC ORGANIZATION AND EXPRESSION OF THE WT1 GENE [J].

GESSLER, M ;

KONIG, A ;

BRUNS, GAP .

GENOMICS, 1992, 12 (04) :807-813

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