Autosomal recessive inheritance of affective disorders in families of responders to lithium prophylaxis?

被引:27
作者
Alda, M
Grof, E
Cavazzoni, P
Duffy, A
Martin, R
Ravindran, L
Grof, P
机构
[1] Department of Psychiatry, Institute of Mental Health Research, University of Ottawa, Ottawa, Ont.
关键词
lithium; affective disorders; bipolar disorder; mode of inheritance; heterogeneity;
D O I
10.1016/S0165-0327(97)00042-6
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In this paper we report the results of a study of the mode of inheritance in affective disorders responsive to lithium. Earlier we described a series of 71 families in which the genetic transmission was compatible with a single-gene model. We have now carried out an independent replication study on 25 newly recruited families in a different geographical location. The autosomal recessive model from our original study could not be rejected with the new data. In a subsequent analysis of the pooled sample of 96 families, a recessive model with a common predisposing allele (q=0.16) and sex-specific penetrance (0.35 in males, 0.66 in females) fitted the data best. On the other hand, X-chromosome and polygenic models could be rejected. The finding of a major-gene effect represents a specific hypothesis that can be tested by molecular genetic techniques. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:153 / 157
页数:5
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