Compensatory dendritic cell development mediated by BATF-IRF interactions

被引：315

作者：

Tussiwand, Roxane ^{[1
]}

Lee, Wan-Ling ^{[1
]}

Murphy, Theresa L. ^{[1
]}

Mashayekhi, Mona ^{[1
]}

Wumesh, K. C. ^{[1
]}

Albring, Joern C. ^{[1
]}

Satpathy, Ansuman T. ^{[1
]}

Rotondo, Jeffrey A. ^{[1
]}

Edelson, Brian T. ^{[1
]}

Kretzer, Nicole M. ^{[1
]}

Wu, Xiaodi ^{[1
]}

Weiss, Leslie A. ^{[2
]}

Glasmacher, Elke ^{[3
]}

Li, Peng ^{[4
,5
]}

Liao, Wei ^{[4
,5
]}

Behnke, Michael ^{[2
]}

Lam, Samuel S. K. ^{[1
]}

Aurthur, Cora T. ^{[1
]}

Leonard, Warren J. ^{[4
,5
]}

Singh, Harinder ^{[3
]}

Stallings, Christina L. ^{[2
]}

Sibley, L. David ^{[2
]}

Schreiber, Robert D. ^{[1
]}

Murphy, Kenneth M. ^{[1
,6
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[3] Genentech Inc, Dept Discovery Immunol, San Francisco, CA 94080 USA

[4] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

[5] NHLBI, Ctr Immunol, NIH, Bethesda, MD 20892 USA

[6] Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA

来源：

NATURE | 2012年 / 490卷 / 7421期

基金：

美国国家卫生研究院;

关键词：

NEGATIVE REGULATOR; B-ATF; CD8-ALPHA(+); TRANSCRIPTION; EXPRESSION; INFECTION; AP-1; REVEALS; MICE; ACTIVATION;

D O I：

10.1038/nature11531

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The AP1 transcription factor Batf3 is required for homeostatic development of CD8 alpha(+) classical dendritic cells that prime CD8 T-cell responses against intracellular pathogens. Here we identify an alternative, Batf3-independent pathway in mice for CD8 alpha(+) dendritic cell development operating during infection with intracellular pathogens and mediated by the cytokines interleukin (IL)-12 and interferon-gamma. This alternative pathway results from molecular compensation for Batf3 provided by the related AP1 factors Batf, which also functions in T and B cells, and Batf2 induced by cytokines in response to infection. Reciprocally, physiological compensation between Batf and Batf3 also occurs in T cells for expression of IL-10 and CTLA4. Compensation among BATF factors is based on the shared capacity of their leucine zipper domains to interact with non-AP1 factors such as IRF4 and IRF8 to mediate cooperative gene activation. Conceivably, manipulating this alternative pathway of dendritic cell development could be of value in augmenting immune responses to vaccines.

引用

页码：502 / +

页数：9

共 47 条

[1] Essential role for ICSBP in the in vivo development of murine CD8α+ dendritic cells [J].

Aliberti, J ;

Schulz, O ;

Pennington, DJ ;

Tsujimura, H ;

Sousa, CRE ;

Ozato, K ;

Sher, A .

BLOOD, 2003, 101 (01) :305-310

[2] CX3CR1+ CD8α+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells [J].

Bar-On, Liat ;

Birnberg, Tal ;

Lewis, Kanako L. ;

Edelson, Brian T. ;

Bruder, Dunja ;

Hildner, Kai ;

Buer, Jan ;

Murphy, Kenneth M. ;

Reizis, Boris ;

Jung, Steffen .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (33) :14745-14750

[3] Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases [J].

Behnke, Michael S. ;

Khan, Asis ;

Wootton, John C. ;

Dubey, Jitender P. ;

Tang, Keliang ;

Sibley, L. David .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (23) :9631-9636

[4] Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice [J].

Bending, David ;

De La Pena, Hugo ;

Veldhoen, Marc ;

Phillips, Jenny M. ;

Uyttenhove, Catherine ;

Stockinger, Brigitta ;

Cooke, Anne .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (03) :565-572

[5] Batf coordinates multiple aspects of B and T cell function required for normal antibody responses [J].

Betz, Briana C. ;

Jordan-Williams, Kimberly L. ;

Wang, Chuanwu ;

Kang, Seung Goo ;

Liao, Juan ;

Logan, Michael R. ;

Kim, Chang H. ;

Taparowsky, Elizabeth J. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (05) :933-942

[6] Assembly requirements of PU.1-Pip (IRF-4) activator complexes:: inhibiting function in vivo using fused dimers [J].

Brass, AL ;

Zhu, AQ ;

Singh, H .

EMBO JOURNAL, 1999, 18 (04) :977-991

[7] The development of inflammatory TH-17 cells requires interferon-regulatory factor 4 [J].

Bruestle, Anne ;

Heink, Sylvia ;

Huber, Magdalena ;

Rosenplaenter, Christine ;

Stadelmann, Christine ;

Yu, Philipp ;

Arpaia, Enrico ;

Mak, Tak W. ;

Kamradt, Thomas ;

Lohoff, Michael .

NATURE IMMUNOLOGY, 2007, 8 (09) :958-966

[8] Structure of the DNA binding domains from NFAT, Fos and Jun bound specifically to DNA [J].

Chen, L ;

Glover, JNM ;

Hogan, PG ;

Rao, A ;

Harrison, SC .

NATURE, 1998, 392 (6671) :42-48

[9] CD8+ but not CD8- dendritic cells cross-prime cytotoxic T cells in vivo [J].

den Haan, JMM ;

Lehar, SM ;

Bevan, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (12) :1685-1695

[10] ACCURATE TRANSCRIPTION INITIATION BY RNA POLYMERASE-II IN A SOLUBLE EXTRACT FROM ISOLATED MAMMALIAN NUCLEI [J].

DIGNAM, JD ;

LEBOVITZ, RM ;

ROEDER, RG .

NUCLEIC ACIDS RESEARCH, 1983, 11 (05) :1475-1489

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