Inhibitory effects of caffeic acid ethyl ester on H2O2-induced cytotoxicity and DNA single-strand breaks in Chinese hamster V79 cells

被引：12

作者：

Nakayama, T ^{[1
]}

Yamada, M ^{[1
]}

Osawa, T ^{[1
]}

Kawakishi, S ^{[1
]}

机构：

[1] NAGOYA UNIV, DEPT APPL BIOL SCI, NAGOYA, AICHI 46401, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1996年 / 60卷 / 02期

关键词：

hydrogen peroxide; cultured cell; DNA strand break; caffeic acid ethyl ester; polyphenol;

D O I：

10.1271/bbb.60.316

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytotoxicity and DNA single-strand breaks caused by H2O2 were assessed by a colony formation assay and a DNA precipitation assay, respectively, with Chinese hamster V79 cells, In both assays, caffeic acid ethyl ester showed protective effects, The structure-activity relationship showed that the o-dihydroxy structure of caffeic acid ethyl ester was essential for the protective effects.

引用

页码：316 / 318

页数：3

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