Cellular radiation effects and the bystander response

被引：102

作者：

Little, John B. ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Ctr Radiat Sci & Environm Hlth, Boston, MA 02115 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2006年 / 597卷 / 1-2期

关键词：

bystander effect; genomic instability; DNA repair; genetic susceptibility; gap junction intercellular communication; oxidative stress;

D O I：

10.1016/j.mrfmmm.2005.12.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This report reviews briefly some of the findings reported over the past 2 years that enhance our understanding of the radiation-induced bystander effect. These developments include: technicological advances; the role of oxidative stress; the effect of cytoplasmic irradiation; cell-to-cell communication; and evidence that Connexin 43 mediated intercellular communication is induced by radiation exposure. A few overriding unanswered questions are discussed. These include: what is the signal(s) transmitted from irradiated to bystander cells; what is the relationship between the bystander response and other non-targeted effects of radiation; are there beneficial effects associated with the bystander response; and what is the significance of the bystander effect for radiation protection? (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：113 / 118

页数：6

共 49 条

[1] Stress signaling frorn irradiated to non-irradiated cells [J].

Azzam, EI ;

de Toledo, SM ;

Little, JB .

CURRENT CANCER DRUG TARGETS, 2004, 4 (01) :53-64

[2]

Azzam EI, 2003, CANCER RES, V63, P7128

[3] Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect [J].

Azzam, EI ;

de Toledo, SM ;

Little, JB .

ONCOGENE, 2003, 22 (45) :7050-7057

[4] A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation [J].

Belyakov, OV ;

Folkard, M ;

Mothersill, C ;

Prise, KM ;

Michael, BD .

BRITISH JOURNAL OF CANCER, 2003, 88 (05) :767-774

[5] Gap junction communication dynamics and bystander effects from ultrasoft X-rays [J].

Edwards, GO ;

Botchway, SW ;

Hirst, G ;

Wharton, CW ;

Chipman, JK ;

Meldrum, RA .

BRITISH JOURNAL OF CANCER, 2004, 90 (07) :1450-1456

[6]

Folkard M, 2001, RADIAT RES, V156, P796, DOI 10.1667/0033-7587(2001)156[0796:AFUXRM]2.0.CO

[7]

[8] Proliferative response of bystander cells adjacent to cells with incorporated radioactivity [J].

Gerashchenko, BI ;

Howell, RW .

CYTOMETRY PART A, 2004, 60A (02) :155-164

[9] Cell proximity is a prerequisite for the proliferative response of bystander cells co-cultured with cells irradiated with γ-rays [J].

Gerashchenko, BI ;

Howell, RW .

CYTOMETRY PART A, 2003, 56A (02) :71-80

[10] Low dose ionizing radiation-induced activation of connexin 43 expression [J].

Glover, D ;

Little, JB ;

Lavin, MF ;

Gueven, N .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2003, 79 (12) :955-964

← 1 2 3 4 5 →