Overview of the yeast genome

被引：435

作者：

Mewes, HW ^{[1
]}

Albermann, K ^{[1
]}

Bahr, M ^{[1
]}

Frishman, D ^{[1
]}

Gleissner, A ^{[1
]}

Hani, J ^{[1
]}

Heumann, K ^{[1
]}

Kleine, K ^{[1
]}

Maierl, A ^{[1
]}

Oliver, SG ^{[1
]}

Pfeiffer, F ^{[1
]}

Zollner, A ^{[1
]}

机构：

[1] UNIV MANCHESTER,INST SCI & TECHNOL,MANCHESTER M60 1QD,LANCS,ENGLAND

来源：

NATURE | 1997年 / 387卷 / 6632期

关键词：

D O I：

10.1038/387s007

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The collaboration of more than 600 scientists from over 100 laboratories to sequence the Saccharomyces cerevisiae genome was the largest decentralised experiment in modern molecular biology and resulted in a unique data resource representing the first complete set of genes from a eukaryotic organism, 12 million bases were sequenced in a truly international effort involving European, US, Canadian and Japanese laboratories. While the yeast genome represents only a small fraction of the information in today's pubic sequence databases, the complete, ordered and non-redundant sequence provides an invaluable resource for the detailed analysis of cellular gene function and genome architecture. In terms of throughput, completeness and information content, yeast has always been the lead eukaryotic organism in genomics; it is still the largest genome to be completely sequenced.

引用

页码：7 / 8

页数：2

共 10 条

[1] The PROSITE database, its status in 1995
Bairoch, A
Bucher, P
Hofmann, K
[J]. NUCLEIC ACIDS RESEARCH, 1996, 24 (01) : 189 - 196
[2] COMPREHENSIVE SEQUENCE-ANALYSIS OF THE 182 PREDICTED OPEN READING FRAMES OF YEAST CHROMOSOME-III
BORK, P
OUZOUNIS, C
SANDER, C
SCHARF, M
SCHNEIDER, R
SONNHAMMER, E
[J]. PROTEIN SCIENCE, 1992, 1 (12) : 1677 - 1690
[3] CHALLENGING TIMES FOR BIOINFORMATICS
CASARI, G
ANDRADE, MA
BORK, P
BOYLE, J
DARUVAR, A
OUZOUNIS, C
SCHNEIDER, R
TAMAMES, J
VALENCIA, A
SANDER, C
[J]. NATURE, 1995, 376 (6542) : 647 - 648
[4] DAYHOFF MO, 1976, FED PROC, V35, P2132
[5] Life with 6000 genes
Goffeau, A
Barrell, BG
Bussey, H
Davis, RW
Dujon, B
Feldmann, H
Galibert, F
Hoheisel, JD
Jacq, C
Johnston, M
Louis, EJ
Mewes, HW
Murakami, Y
Philippsen, P
Tettelin, H
Oliver, SG
[J]. SCIENCE, 1996, 274 (5287) : 546 - &
[6] HEUMANN K, 1996, P 4 INT C INT SYST M, P98
[7] YEAST CHROMOSOME-III - NEW GENE FUNCTIONS
KOONIN, EV
BORK, P
SANDER, C
[J]. EMBO JOURNAL, 1994, 13 (03) : 493 - 503
[8] A network approach to the systematic analysis of yeast gene function
Oliver, S
[J]. TRENDS IN GENETICS, 1996, 12 (07) : 241 - 242
[9] IMPROVED TOOLS FOR BIOLOGICAL SEQUENCE COMPARISON
PEARSON, WR
LIPMAN, DJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (08) : 2444 - 2448
[10] FUNCTIONS OF THE GENE-PRODUCTS OF ESCHERICHIA-COLI
RILEY, M
[J]. MICROBIOLOGICAL REVIEWS, 1993, 57 (04) : 862 - 952

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