Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity

被引：42

作者：

Hong, JY

Yang, CS

机构：

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 1997年 / 105卷

关键词：

cytochrome P450; metabolism; genetic polymorphisms; biomarker; susceptibility; cancer risk; environmental toxicity;

D O I：

10.2307/3433280

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Cytochrome P450 (CYP) enzymes are responsible for the metabolism of numerous xenobiotics and endogenous compounds, including the metabolic activation of most environmental toxic chemicals and carcinogens. Both metabolic and genetic polymorphisms have been identified for human CYP enzymes. The association of CYP genetic polymorphism and human cancer risk, and susceptibility to environmental hazards, have received increasing attention. This article briefly reviews the approaches and methods currently used in CYP genetic polymorphism studies. In addition, the current status and perspectives of using CYP genetic polymorphism as a biomarker of individual susceptibility to cancer and environmental toxicity are discussed.

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页码：759 / 762

页数：4

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