SIRT1 is a circadian deacetylase for core clock components

被引：101

作者：

Belden, William J. ^{[1
]}

Dunlap, Jay C. ^{[1
]}

机构：

[1] Dartmouth Med Sch, Dept Genet, Hanover, NH 03755 USA

来源：

CELL | 2008年 / 134卷 / 02期

关键词：

D O I：

10.1016/j.cell.2008.07.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcriptional activator CLOCK is a histone acetyltransferase that is required for the circadian expression of many genes. Asher et al. (2008) and Nakahata et al. (2008) now demonstrate that the NAD(+)-dependent enzyme SIRT1 functions as a histone deacetylase that counteracts the activity of CLOCK. These results broaden our understanding of the impact of cellular metabolism on the circadian system.

引用

页码：212 / 214

页数：3

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