Insulin-lowering therapeutic modalities for polycystic ovary syndrome

被引:37
作者
Ehrmann, DA [1 ]
机构
[1] Univ Chicago, Pritzker Sch Med, Dept Med, Endocrinol Sect, Chicago, IL 60637 USA
关键词
D O I
10.1016/S0889-8529(05)70078-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This article summarizes the relationship between insulin and androgen excess, with a focus on what is known regarding two related issues in polycystic ovary syndrome: (1) defects in insulin secretion in PCOS and their role in the development of glucose intolerance in this population; and (2) pharmacologic interventions designed to attenuate hyperinsulinemia and its sequelae in PCOS.
引用
收藏
页码:423 / +
页数:17
相关论文
共 56 条
[1]   Can metformin reduce insulin resistance in polycystic ovary syndrome? [J].
Acbay, O ;
Gundogdu, S .
FERTILITY AND STERILITY, 1996, 65 (05) :946-949
[2]  
Achard C., 1921, B ACAD NAT MED PARIS, V86, P51
[3]   CORRELATION OF HYPERANDROGENISM WITH HYPERINSULINISM IN POLYCYSTIC OVARIAN DISEASE [J].
BURGHEN, GA ;
GIVENS, JR ;
KITABCHI, AE .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1980, 50 (01) :113-116
[4]   Troglitazone use in insulin-treated type 2 diabetic patients [J].
Buse, JB ;
Gumbiner, B ;
Mathias, NP ;
Nelson, DM ;
Faja, BW ;
Whitcomb, RW .
DIABETES CARE, 1998, 21 (09) :1455-1461
[5]  
CASIMIRRI F, 1997, INT J OBESITY S2, V21, pS61
[6]   INSULIN RESISTANCE IN NON-OBESE PATIENTS WITH POLYCYSTIC OVARIAN DISEASE [J].
CHANG, RJ ;
NAKAMURA, RM ;
JUDD, HL ;
KAPLAN, SA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1983, 57 (02) :356-359
[7]   EFFECTS OF DIET AND METFORMIN ADMINISTRATION ON SEX HORMONE-BINDING GLOBULIN, ANDROGENS, AND INSULIN IN HIRSUTE AND OBESE WOMEN [J].
CRAVE, JC ;
FIMBEL, S ;
LEJEUNE, H ;
CUGNARDEY, N ;
DECHAUD, H ;
PUGEAT, M .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (07) :2057-2062
[8]  
DAHLGREN E, 1992, FERTIL STERIL, V57, P505
[9]   MECHANISM OF METFORMIN ACTION IN OBESE AND LEAN NONINSULIN-DEPENDENT DIABETIC SUBJECTS [J].
DEFRONZO, RA ;
BARZILAI, N ;
SIMONSON, DC .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 73 (06) :1294-1301
[10]   Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome [J].
Diamanti-Kandarakis, E ;
Kouli, C ;
Tsianateli, T ;
Bergiele, A .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1998, 138 (03) :269-274