High yielding synthesis of heterocyclic β-substituted alanine derivatives

被引：44

作者：

Ferreira, PMT ^{[1
]}

Maia, HLS ^{[1
]}

Monteiro, LS ^{[1
]}

机构：

[1] Univ Minho, Dept Chem, P-4710 Braga, Portugal

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(99)00691-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Heterocyclic P-substituted alanine derivatives such as beta-(pyrazol-1-yl) and beta-(1,2,4-triazol-1-yl)-alanine are synthesized in high yields by a Michael addition of heterocyclic nucleophiles to N,N-bis(tert-butyloxycarbonyl)dehydroalanine methyl ester, using mild reaction conditions and simple work-up procedures. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4099 / 4102

页数：4

共 8 条

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