High yielding synthesis of heterocyclic β-substituted alanine derivatives

被引:44
作者
Ferreira, PMT [1 ]
Maia, HLS [1 ]
Monteiro, LS [1 ]
机构
[1] Univ Minho, Dept Chem, P-4710 Braga, Portugal
关键词
D O I
10.1016/S0040-4039(99)00691-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Heterocyclic P-substituted alanine derivatives such as beta-(pyrazol-1-yl) and beta-(1,2,4-triazol-1-yl)-alanine are synthesized in high yields by a Michael addition of heterocyclic nucleophiles to N,N-bis(tert-butyloxycarbonyl)dehydroalanine methyl ester, using mild reaction conditions and simple work-up procedures. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:4099 / 4102
页数:4
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