Transmissibility, infectivity and immunogenicity of a live human parainfluenza type 3 virus vaccine (HP1V3cp45) among susceptible infants and toddlers

被引：25

作者：

Madhi, SA

Cutland, C

Zhu, YW

Hackell, JG

Newman, F

Blackburn, N

Murphy, BR

Belshe, RB

Karron, RA

Deatly, AM

Gruber, WC

Bernstein, DI

Wright, PF

机构：

[1] Univ Witwatersrand, MRC, Resp & Meningeal Pathogens Res Unit, ZA-2050 Johannesburg, South Africa

[2] Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA

[3] Wyeth Res, Viral Vaccines, Pearl River, NY USA

[4] St Louis Univ, Div Infect Dis & Immunol, St Louis, MO 63103 USA

[5] Natl Inst Communicable Dis, Johannesburg, South Africa

[6] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA

[7] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[8] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[9] Childrens Hosp, Med Ctr, Cincinnati, OH 45229 USA

来源：

VACCINE | 2006年 / 24卷 / 13期

关键词：

parainfluenza virus type 3; vaccine; live-attenuated; transmissibility; immunogenicity; safety;

D O I：

10.1016/j.vaccine.2005.12.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: This study examined the transmissibility between young children of an intranasally administered live attenuated human parainfluenza virus type 3 (HPIV3)-cp45 vaccine candidate. Methods: Eighty subjects were enrolled in playgroups among whom there was at least one infected vaccinee in close contact with a seronegative placebo recipient over 21 days without a confounding infection with wtHPIV3. Following vaccination viral cultures were obtained on nine occasions to detect shedding and transmission of HPIV3cp45. Serum antibody titers were measured before and 7 weeks after vaccination. Results: No child fulfilled the criteria for transmission of HPIV3cp45 giving a risk of transmission of 0.04 (95% Cl 0.01-0.19), hence establishing that HPIV3cp45 is less infectious than wtHPIV3 and risk of transmission is not a limitation to further clinical development of this vaccine candidate. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2432 / 2439

页数：8

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