A highly efficient synthesis of (S)-(+)-N-Boc-coniine using ring-closing olefin metathesis (RCM)

被引：31

作者：

Jo, E ^{[1
]}

Na, Y ^{[1
]}

Chang, S ^{[1
]}

机构：

[1] Ewha Womans Univ, Dept Chem, Seoul 120750, South Korea

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(99)01081-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically active (S)-(+)-coniine as an N-Boc protected form was concisely prepared starting from an amino acid, L-norvaline. The key step involved a ring-closing olefin metathesis (RCM) of the dialkenyl compound 6 to give the corresponding cyclic olefin 8 in an essentially quantitative yield. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：5581 / 5582

页数：2

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