Insulin resistance and bone: a biological partnership

被引：133

作者：

Conte, Caterina ^{[1
]}

Epstein, Solomon ^{[2
]}

Napoli, Nicola ^{[3
,4
]}

机构：

[1] IRCCS San Raffaele Sci Inst, Div Immunol Transplantat & Infect Dis, Clin Transplant Unit, Via Olgettina 60, I-20163 Milan, Italy

[2] Mt Sinai Sch Med, Div Endocrinol, New York, NY USA

[3] Univ Campus Biomed Roma, Div Endocrinol & Diabet, Rome, Italy

[4] Washington Univ, Div Bone & Mineral Dis, St Louis, MO USA

来源：

ACTA DIABETOLOGICA | 2018年 / 55卷 / 04期

关键词：

Insulin; Obesity; Osteocalcin; Type; 2; diabetes; Bone mineral density; Bone turnover markers; GLUCAGON-LIKE PEPTIDE-1; TYPE-2; DIABETES-MELLITUS; SERUM TOTAL OSTEOCALCIN; Y GASTRIC BYPASS; VITAMIN-K STATUS; MINERAL DENSITY; FRACTURE RISK; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; BODY-WEIGHT;

D O I：

10.1007/s00592-018-1101-7

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Despite a clear association between type 2 diabetes (T2D) and fracture risk, the pathogenesis of bone fragility in T2D has not been clearly elucidated. Insulin resistance is the primary defect in T2D. Insulin signalling regulates both bone formation and bone resorption, but whether insulin resistance can affect bone has not been established. On the other hand, evidence exists that bone might play a role in the regulation of glucose metabolism. This article reviews the available experimental and clinical evidence on the interplay between bone and insulin resistance. Interestingly, a bilateral relationship between bone and insulin resistance seems to exist that unites them in a biological partnership.

引用

页码：305 / 314

页数：10

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