Circulatory and diuretic effects of dopexamine infusion in low birth weight infants with respiratory failure

被引:11
作者
Kawczynski, P
Piotrowski, A
机构
关键词
neonate; dopexamine; blood pressure; urine output;
D O I
10.1007/BF01728334
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Objective. To investigate the effects of infusion of dopexamine hydrochloride, a new synthetic: catecholamine, on cardiopulmonary status and urine output in neonates with respiratory and circulatory failure. Design. Prospective clinical study with each patient serving as his own control. Setting. Intensive care unit (14 beds) in a 300-bed paediatric teaching: hospital. Patients. Seventeen neonates with low birth weight (LEW) requiring mechanical ventilation in the first 4 days of life, who initially had two of the following symptoms: hypotension, oliguria, metabolic acidosis with base deficit > 10 and failure to respond to volume loading. lnterventions. Cardiopulmonary variables, diuresis and acid-base status were measured before and after volume loading, in patients who did not improve infusion of doper;amine was started at a dose of 2 mu g kg(-1) min(-1) which was titrated to achieve blood pressure, urine output, and base deficit in normal range. Observations were continued for a period of 5 h. Measurements and results. Systolic blood pressure increased significantly after 3 h. of dopexamine infusion and remained elevated up to the end of the study period. Diastolic and mean blood pressure increased slightly (NS). Diuresis increased significantly from the 4th h of dopexamine infusion. Arterial blood pH increased significantly from baseline at 5 h after the start of dopexamine administration. There was also a significant imporovement in the PtcO(2)/PaO2 index. Conclusion. In neonates with respiratory and circulatory failure, dopexamine increases blood pressure and improves arterial pH and urine output.
引用
收藏
页码:65 / 70
页数:6
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