Roadmap to embryo implantation: clues from mouse models

被引：1043

作者：

Wang, HB

Dey, SK ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Pediat, Div Reprod & Dev Biol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Cell & Dev Biol, Div Reprod & Dev Biol, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Div Reprod & Dev Biol, Nashville, TN 37232 USA

来源：

NATURE REVIEWS GENETICS | 2006年 / 7卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg1808

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Implantation involves an intricate discourse between the embryo and uterus and is a gateway to further embryonic development. Synchronizing embryonic development until the blastocyst stage with the uterine differentiation that takes place to produce the receptive state is crucial to successful implantation, and therefore to pregnancy outcome. Although implantation involves the interplay of numerous signalling molecules, the hierarchical instructions that coordinate the embryo - uterine dialogue are not well understood. This review highlights our knowledge about the molecular development of preimplantation and implantation and the future challenges of the field. A better understanding of periimplantation biology could alleviate female infertility and help to develop novel contraceptives.

引用

收藏

页码：185 / 199

页数：15

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