Immune Dysregulation and Chronic Stress among Older Adults: A Review

被引：180

作者：

Gouin, Jean-Philippe ^{[1
,2
]}

Hantsoo, Liisa ^{[1
,2
]}

Kiecolt-Glaser, Janice K. ^{[1
,2
,3
]}

机构：

[1] Ohio State Univ, Coll Med, Inst Behav Med Res, Columbus, OH 43210 USA

[2] Ohio State Univ, Coll Med, Dept Psychol, Columbus, OH 43210 USA

[3] Ohio State Univ, Coll Med, Dept Psychiat, Columbus, OH 43210 USA

来源：

NEUROIMMUNOMODULATION | 2008年 / 15卷 / 4-6期

关键词：

Chronic Stress; Immune Dysregulation; Aging; Vaccine; Herpesviruses; Interleukin-6; Inflammation; Telomeres; Psychoneuroimmunology;

D O I：

10.1159/000156468

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aging is associated with a natural dysregulation in immune functioning which may be amplified when it occurs in the context of chronic stress. Family dementia caregiving provides an excellent model to study the impact of chronic stress on immune functioning among older individuals. Empirical data suggest that the stress of caregiving dysregulates multiple components of innate and adaptive immunity. Elderly caregivers have poorer responses to vaccines, impaired control of latent viruses, exaggerated production of inflammatory mediators and accelerated cellular aging, compared to noncaregiving older adults. The chronic stress-induced immune dysregulation observed among older caregivers appears to be of sufficient magnitude to impact health. Furthermore, evidence suggests that chronic stress leads to premature aging of the immune system. Copyright (C) 2008 S. Karger AG, Basel

引用

页码：251 / 259

页数：9

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