Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths

被引：371

作者：

Gause, William C. ^{[1
]}

Wynn, Thomas A. ^{[2
,3
]}

Allen, Judith E. ^{[4
]}

机构：

[1] Rutgers State Univ, New Jersey Med Sch, Dept Med, Ctr Immun & Inflammat, Newark, NJ 07103 USA

[2] NIAID, Immunopathogenesis Sect, Program Tissue Immun & Repair, NIH, Bethesda, MD 20892 USA

[3] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[4] Univ Edinburgh, Sch Biol Sci, Ctr Immun Infect & Evolut, Edinburgh EH9 3JT, Midlothian, Scotland

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 08期

基金：

美国国家卫生研究院;

关键词：

ALTERNATIVELY ACTIVATED MACROPHAGES; HYGIENE HYPOTHESIS; T(H)2-TYPE RESPONSES; AIRWAY INFLAMMATION; PROTECTIVE IMMUNITY; PROTEIN-SYNTHESIS; INNATE EFFECTOR; CELL-POPULATION; GENE-EXPRESSION; TH2; RESPONSES;

D O I：

10.1038/nri3476

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.

引用

页码：607 / 614

页数：8

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