Intrinsic macrolide resistance of the Mycobacterium tuberculosis complex is inducible

被引：46

作者：

Andini, Nadya

Nash, Kevin A.

机构：

[1] Childrens Hosp, Saban Res Inst, Dept Pathol & Lab Med, Los Angeles, CA 90027 USA

[2] Univ So Calif, Dept Pathol, Los Angeles, CA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 07期

关键词：

D O I：

10.1128/AAC.00264-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mycobacterium tuberculosis is intrinsically resistant to macrolides, a characteristic associated with expression of the erm (37) gene. This intrinsic resistance was found to be inducible with clarithromycin and the ketolide HMR3004. Furthermore, underlying the phenotypic induction was an increase in erm(37) mRNA levels.

引用

收藏

页码：2560 / 2562

页数：3

相关论文

共 15 条

[1] Molecular basis of intrinsic macrolide resistance in the Mycobacterium tuberculosis complex [J].

Buriánková, K ;

Doucet-Populaire, F ;

Dorson, O ;

Gondran, A ;

Ghnassia, JC ;

Weiser, J ;

Pernodet, JL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (01) :143-150

[2] Microplate Alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium [J].

Collins, LA ;

Franzblau, SG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) :1004-1009

[3] In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis [J].

Falzari, K ;

Zhu, ZH ;

Pan, DH ;

Liu, HW ;

Hongmanee, P ;

Franzblau, SG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (04) :1447-1454

[4] In-vitro activity of fluorinated quinolones and macrolides against drug-resistant Mycobacterium tuberculosis [J].

Hoffner, SE ;

Gezelius, L ;

Olsson-Liljequist, B .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 (06) :885-888

[5] ANTITUBERCULOSIS ACTIVITY OF CLARITHROMYCIN [J].

LUNAHERRERA, J ;

REDDY, VM ;

DANELUZZI, D ;

GANGADHARAM, PRJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (12) :2692-2695

[6] Methyltransferase Erm(37) slips on rRNA to confer atypical resistance in Mycobacterium tuberculosis [J].

Madsen, CT ;

Jakobsen, L ;

Buriánková, K ;

Doucet-Populaire, F ;

Pernodet, JL ;

Douthwaite, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (47) :38942-38947

[7] Ancestral antibiotic resistance in Mycobacterium tuberculosis [J].

Morris, RP ;

Nguyen, L ;

Gatfield, J ;

Visconti, K ;

Nguyen, K ;

Schnappinger, D ;

Ehrt, S ;

Liu, Y ;

Heifets, L ;

Pieters, J ;

Schoolnik, G ;

Thompson, CJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (34) :12200-12205

[8] Molecular basis of intrinsic macrolide resistance in clinical isolates of Mycobacterium fortuitum [J].

Nash, KA ;

Zhang, YS ;

Brown-Elliott, BA ;

Wallace, RJ .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 55 (02) :170-177

[9] Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm Gene, erm(38) [J].

Nash, KA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (10) :3053-3060

[10]

NASH KA, 2004, 44 INT C ANT AG CHEM, P67