Artificial viruses: a nanotechnological approach to gene delivery

被引：280

作者：

Mastrobattista, E ^{[1
]}

van der Aa, MAEM ^{[1
]}

Hennink, WE ^{[1
]}

Crommelin, DJA ^{[1
]}

机构：

[1] Univ Utrecht, Dept Pharmaceut, UIPS, Utrecht, Netherlands

来源：

NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 02期

关键词：

D O I：

10.1038/nrd1960

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nanotechnology is a rapidly expanding multidisciplinary field in which highly sophisticated nanoscale devices are constructed from atoms, molecules or ( macro) molecular assemblies. In the field of gene medicine, systems for delivering nucleic acids are being developed that incorporate virus-like functions in a single nanoparticle. Although their development is still in its infancy, it is expected that such artificial viruses will have a great impact on the advancements of gene therapeutics.

引用

页码：115 / 121

页数：7

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