Plasmodium falciparum: Direct cloning and expression of pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase domains

被引：14

作者：

HekmatNejad, M

Lee, PC

Rathod, PK

机构：

[1] Institute for Biomolecular Studies, Department of Biology, Catholic University of America, Washington

来源：

EXPERIMENTAL PARASITOLOGY | 1997年 / 85卷 / 03期

关键词：

malaria; Plasmodium falciparum; pyrimethamine;

D O I：

10.1006/expr.1997.4145

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

[No abstract available]

引用

页码：303 / 305

页数：3

共 19 条

[1]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[2]

CARRINGTON HC, 1951, NATURE, V16, P1080

[3] Characterization of promoters and stable transfection by homologous and nonhomologous recombination in Plasmodium falciparum [J].

Crabb, BS ;

Cowman, AF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (14) :7289-7294

[4] STABLE MOLECULAR-TRANSFORMATION OF TOXOPLASMA-GONDII - A SELECTABLE DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE MARKER BASED ON DRUG-RESISTANCE MUTATIONS IN MALARIA [J].

DONALD, RGK ;

ROOS, DS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :11703-11707

[5]

FERONE R, 1969, MOL PHARMACOL, V5, P49

[6] AMINO-ACIDS IN THE DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE GENE OF PLASMODIUM-FALCIPARUM INVOLVED IN CYCLOGUANIL RESISTANCE DIFFER FROM THOSE INVOLVED IN PYRIMETHAMINE RESISTANCE [J].

FOOTE, SJ ;

GALATIS, D ;

COWMAN, AF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :3014-3017

[7] FUNCTIONAL EXPRESSION OF THE DIHYDROFOLATE-REDUCTASE AND THYMIDYLATE SYNTHETASE ACTIVITIES OF THE HUMAN MALARIA PARASITE PLASMODIUM-FALCIPARUM IN ESCHERICHIA-COLI [J].

HALL, SJ ;

SIMS, PFG ;

HYDE, JE .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1991, 45 (02) :317-330

[8] Kinetics of Plasmodium falciparum thymidylate synthase: Interactions with high-affinity metabolites of 5-fluoroorotate and D1694 [J].

HekmatNejad, M ;

Rathod, PK .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (07) :1628-1632

[9]

HITCHINGS GH, 1960, CLIN PHARMACOL THER, V1, P570

[10] MOLECULAR-BASIS OF DIFFERENTIAL RESISTANCE TO CYCLOGUANIL AND PYRIMETHAMINE IN PLASMODIUM-FALCIPARUM MALARIA [J].

PETERSON, DS ;

MILHOUS, WK ;

WELLEMS, TE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :3018-3022

← 1 2 →