Optical detection of synaptic vesicle exocytosis and endocytosis

被引:32
作者
Murthy, VN [1 ]
机构
[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
关键词
D O I
10.1016/S0959-4388(99)80046-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent advances in optical methods have catalyzed a detailed study of individual visualized synapses in several model systems. Quantal events at small central synapses, as well as single granule exocytosis in secretory cells, have been detected using quantitative fluorescence imaging. Sensitive detection of exocytosis and endocytosis at individual synapses has advanced our knowledge of synaptic vesicle trafficking.
引用
收藏
页码:314 / 320
页数:7
相关论文
共 51 条
[1]   The exocytotic event in chromaffin cells revealed by patch amperometry [J].
Albillos, A ;
Dernick, G ;
Horstmann, H ;
Almers, W ;
deToledo, GA ;
Lindau, M .
NATURE, 1997, 389 (6650) :509-512
[2]  
Axelrod D, 1991, TOPICS FLUORESCENCE, V3, P289
[3]   Imaging exocytosis and endocytosis [J].
Betz, WJ ;
Mao, F ;
Smith, CB .
CURRENT OPINION IN NEUROBIOLOGY, 1996, 6 (03) :365-371
[4]   OPTICAL ANALYSIS OF SYNAPTIC VESICLE RECYCLING AT THE FROG NEUROMUSCULAR-JUNCTION [J].
BETZ, WJ ;
BEWICK, GS .
SCIENCE, 1992, 255 (5041) :200-203
[5]   Pre- and postsynaptic whole-cell recordings in the medial nucleus of the trapezoid body of the rat [J].
Borst, JGG ;
Helmchen, F ;
Sakmann, B .
JOURNAL OF PHYSIOLOGY-LONDON, 1995, 489 (03) :825-840
[6]   Neuronal peptide release is limited by secretory granule mobility [J].
Burke, NV ;
Han, WP ;
Li, DQ ;
Takimoto, K ;
Watkins, SC ;
Levitan, ES .
NEURON, 1997, 19 (05) :1095-1102
[7]  
Chow Robert H., 1995, P245
[8]   Photon upmanship: Why multiphoton imaging is more than a gimmick [J].
Denk, W ;
Svoboda, K .
NEURON, 1997, 18 (03) :351-357
[9]   SUBTHRESHOLD SYNAPTIC CA2+ SIGNALING IN FINE DENDRITES AND SPINES OF CEREBELLAR PURKINJE NEURONS [J].
EILERS, J ;
AUGUSTINE, GJ ;
KONNERTH, A .
NATURE, 1995, 373 (6510) :155-158
[10]   Single synaptic events evoke NMDA receptor-mediated release of calcium from internal stores in hippocampal dendritic spines [J].
Emptage, N ;
Bliss, TVP ;
Fine, A .
NEURON, 1999, 22 (01) :115-124