Post insult enriched housing improves the 8-arm radial maze performance but not the Morris water maze task in ventral subicular lesioned rats

被引：31

作者：

Bindu, B ^{[1
]}

Rekha, J ^{[1
]}

Kutty, BM ^{[1
]}

机构：

[1] Natl Inst Mental Hlth & Neurosci, Dept Neurophysiol, Bangalore 560029, Karnataka, India

来源：

BRAIN RESEARCH | 2005年 / 1063卷 / 02期

关键词：

ventral subicular lesion; spatial task; impairment; enriched housing; behavioral recovery;

D O I：

10.1016/j.brainres.2005.09.044

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study attempted to evaluate the efficacy of enriched housing conditions in promoting behavioral recovery following subicular lesion. Rats with bilateral ibotenic acid lesions of ventral subiculum were exposed to either enriched housing conditions or standard housing for 6 h daily for 10 days. The performance of the lesioned rats reared in standard housing conditions was severely impaired in both 8-arm radial maze and water maze tasks. Lesioned rats exposed to enriched housing showed behavioral recovery in the 8-arm radial maze but not in the water maze. Our study suggests the possibility that recovery may be based on the functional demand of spatial tasks and may require more appropriate environmental stimulation. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：121 / 131

页数：11

共 50 条

[1] SPATIAL LOCATION LEARNING IN MICE WITH IBOTENATE LESIONS OF ENTORHINAL CORTEX OR SUBICULUM [J].

CHO, YH ;

JAFFARD, R .

NEUROBIOLOGY OF LEARNING AND MEMORY, 1995, 64 (03) :285-290

[2]

DALRYMPLEALFORD JC, 1987, PSYCHOBIOLOGY, V15, P255

[3] PREOPERATIVE DIFFERENTIAL HOUSING AND DORSAL HIPPOCAMPAL-LESIONS IN RATS [J].

DALRYMPLEALFORD, JC ;

BENTON, D .

BEHAVIORAL NEUROSCIENCE, 1984, 98 (01) :23-34

[4]

DALRYMPLEALFORD JC, 1985, ADV BEHAV BIOL, P441

[5] Selective neurodegeneration of hippocampus and entorhinal cortex correlates with spatial learning impairments in rats with bilateral ibotenate lesions of ventral subiculum [J].

Devi, L ;

Diwakar, L ;

Raju, TR ;

Kutty, BM .

BRAIN RESEARCH, 2003, 960 (1-2) :9-15

[6] Environmental enrichment modifies the PKA-dependence of hippocampal LTP and improves hippocampus-dependent memory [J].

Duffy, SN ;

Craddock, KJ ;

Abel, T ;

Nguyen, PV .

LEARNING & MEMORY, 2001, 8 (01) :26-34

[7] EFFECTS OF POSTOPERATIVE ENVIRONMENT ON RECOVERY FROM DORSAL HIPPOCAMPAL-LESIONS IN YOUNG-RATS - TESTS OF SPATIAL MEMORY AND MOTOR TRANSFER [J].

EINON, DF ;

MORGAN, MJ ;

WILL, BE .

QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY, 1980, 32 (FEB) :137-+

[8] Differential effects of lidocaine infusions into the ventral CA1/subiculum or the nucleus accumbens on the acquisition and retention of spatial information [J].

Floresco, SB ;

Seamans, JK ;

Phillips, AG .

BEHAVIOURAL BRAIN RESEARCH, 1996, 81 (1-2) :163-171

[9] Effects of postoperative housing conditions on functional recovery in rats with lesions of the hippocampus, subiculum, or entorhinal cortex [J].

Galani, R ;

Jarrard, LE ;

Will, BE ;

Kelche, C .

NEUROBIOLOGY OF LEARNING AND MEMORY, 1997, 67 (01) :43-56

[10]

Galani R, 1998, RESTOR NEUROL NEUROS, V13, P173

← 1 2 3 4 5 →