Plasma selenium concentration and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)

被引：63

作者：

Allen, Naomi E. ^{[1
]}

Appleby, Paul N.

Roddam, Andrew W.

Tjonneland, Anne ^{[2
]}

Johnsen, Nina Fons ^{[2
]}

Overvad, Kim ^{[3
]}

Boeing, Heiner ^{[4
,5
]}

Weikert, Steffen ^{[4
,5
]}

Kaaks, Rudolf ^{[6
]}

Linseisen, Jakob ^{[6
]}

Trichopoulou, Antonia ^{[7
]}

Misirli, Gesthimani ^{[7
]}

Trichopoulos, Dimitrios ^{[8
,9
]}

Sacerdote, Carlotta ^{[10
]}

Grioni, Sara ^{[11
]}

Palli, Domenico ^{[12
]}

Tumino, Rosario ^{[13
]}

Bueno-de-Mesquita, H. Bas ^{[14
]}

Kiemeney, Lambertus A. ^{[15
]}

Barricarte, Aurelio ^{[16
,17
]}

Larranaga, Nerea ^{[18
]}

Sanchez, Maria-Jose ^{[17
,19
,21
]}

Agudo, Antonio ^{[20
]}

Tormo, Maria-Jose ^{[17
]}

Rodriguez, Laudina ^{[22
]}

Stattin, Paer ^{[23
]}

Hallmans, Goeran ^{[24
]}

Bingham, Sheila ^{[25
]}

Khaw, Kay-Tee ^{[26
]}

Slimani, Nadia ^{[27
]}

Rinaldi, Sabina ^{[27
]}

Boffetta, Paolo ^{[27
]}

Riboli, Elio ^{[28
]}

Key, Timothy J.

机构：

[1] Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Med, Oxford OX3 7LF, England

[2] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[3] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[4] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[5] Charite Univ Med Berlin, Dept Urol, D-13353 Berlin, Germany

[6] German Canc Res Ctr, Div Clin Epidemiol, Heidelberg, Germany

[7] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece

[8] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Cambridge, MA 02138 USA

[9] Hellen Hlth Fdn, Athens, Greece

[10] CPO Piemonte & ISI Fdn, Turin, Italy

[11] Ist Nazl Tumori, Nutr Epidemiol Unit, Fdn IRCCS, I-20133 Milan, Italy

[12] CSPO Sci Inst Tuscany, Mol & Nutr Epidemiol Unit, Florence, Italy

[13] Azienda Osped Civile MP Arezzo, Canc Registry, Ragusa, Italy

[14] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[15] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[16] Publ Hlth Inst Navarra, Pamplona, Spain

[17] CIBER Epidemiol & Salud Publ, Barcelona, Spain

[18] Basque Hlth Dept Gipuzkoa, Epidemiol Unit, San Sebastian, Spain

[19] Andalusian Sch Publ Hlth Granada, Barcelona, Spain

[20] IDIBELL Catalan Inst Oncol, Dept Epidemiol, Barcelona, Spain

[21] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain

[22] Publ Hlth & Hlth Planning Directorate, Asturias, Spain

[23] Umea Univ Hosp, Dept Surg & Perioperat Sci, S-90185 Umea, Sweden

[24] Umea Univ Hosp, Dept Publ Hlth & Clin Med, S-90185 Umea, Sweden

[25] MRC, Ctr Nutr Epidemiol Canc Prevent & Survival, Dept Publ Hlth & Primary Care, Cambridge, England

[26] Univ Cambridge, Dept Gerontol, Cambridge, England

[27] WHO, Int Agcy Res Canc, Lyon, France

[28] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2008年 / 88卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.3945/ajcn.2008.26205

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Some evidence indicates that a low selenium intake may be associated with an increased risk of prostate cancer. Objective: The aim of this study was to investigate the association of plasma selenium concentration with subsequent prostate cancer risk and to examine this association by stage and grade of disease and other factors. Design: A nested case-control study was performed among men in the European Prospective Investigation into Cancer and Nutrition (EPIC). The association between plasma selenium concentration and prostate cancer risk was assessed in 959 men with incident prostate cancer and 1059 matched controls. Results: Overall, plasma selenium concentration was not associated with prostate cancer risk; the multivariate relative risk for men in the highest fifth of selenium concentration compared with the lowest fifth was 0.96 (95% CI: 0.70, 1.31; P for trend = 0.25). There were no significant differences in the association of plasma selenium with risk when analyzed by stage or grade of disease. Similarly, the association of selenium with risk did not differ by smoking status or by plasma alpha- or gamma-tocopherol concentration. Conclusion: Plasma selenium concentration was not associated with prostate cancer risk in this large cohort of European men. Am J Clin Nutr 2008; 88:1567-75.

引用

页码：1567 / 1575

页数：9

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