Prediction of intestinal permeability

被引:292
作者
Egan, WJ [1 ]
Lauri, G [1 ]
机构
[1] Accelrys Inc, ADMET R&D, CN 5350, Princeton, NJ 08543 USA
关键词
ADME; ADMET; drug; passive absorption; intestinal permeability; computational model; QSAR; QSPR;
D O I
10.1016/S0169-409X(02)00004-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This review focuses on computational methods for the prediction of passive intestinal permeability. Existing computational models are surveyed and assessed in terms of descriptors, model type/complexity. speed of computation, predictive performance, and interpretability. Challenges to the successful computational prediction of intestinal permeability, i.e. data quantity, measurement imprecision, confounding factors such as solubility, metabolism, or active efflux, and the need for robust statistical methods, are also discussed. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:273 / 289
页数:17
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