Prediction of intestinal permeability

被引：292

作者：

Egan, WJ ^{[1
]}

Lauri, G ^{[1
]}

机构：

[1] Accelrys Inc, ADMET R&D, CN 5350, Princeton, NJ 08543 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2002年 / 54卷 / 03期

关键词：

ADME; ADMET; drug; passive absorption; intestinal permeability; computational model; QSAR; QSPR;

D O I：

10.1016/S0169-409X(02)00004-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review focuses on computational methods for the prediction of passive intestinal permeability. Existing computational models are surveyed and assessed in terms of descriptors, model type/complexity. speed of computation, predictive performance, and interpretability. Challenges to the successful computational prediction of intestinal permeability, i.e. data quantity, measurement imprecision, confounding factors such as solubility, metabolism, or active efflux, and the need for robust statistical methods, are also discussed. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：273 / 289

页数：17

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