Upon activation, quiescent naive T cells undergo a growth phase followed by massive clonal expansion and differentiation that are essential for appropriate immune defense and regulation. Accumulation of cell biomass during the initial growth and rapid proliferation during the expansion phase is associated with dramatically increased bioenergetic and biosynthetic demands. This not only requires a metabolic rewiring during the transition between resting and activation but also addicts active T cells to certain metabolic pathways in ways that naive and memory T cells are not. We consider such addiction in terms of the biological effects of deprivation of metabolic substrates or inhibition of specific pathways in T cells. In this review, we illustrate the relevant metabolic pathways revealed by recent metabolic flux analysis and discuss the consequences of metabolic intervention on specific metabolic pathways in T lymphocytes.
机构:Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Bensinger, Steven J.
Bradley, Michelle N.
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机构:Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Bradley, Michelle N.
Joseph, Sean B.
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机构:Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Joseph, Sean B.
Zelcer, Noam
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机构:Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Zelcer, Noam
Janssen, Edith M.
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La Jolla Inst Allergy & Immunol, La Jolla, CA 92037 USAUniv Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Janssen, Edith M.
Hausner, Mary Ann
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Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USAUniv Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Hausner, Mary Ann
Shih, Roger
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Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USAUniv Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Shih, Roger
Parks, John S.
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Wake Forest Univ, Sch Med, Dept Pathol, Winston Salem, NC 27157 USAUniv Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Parks, John S.
Edwards, Peter A.
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机构:
Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90049 USAUniv Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Edwards, Peter A.
Jamieson, Beth D.
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h-index: 0
机构:
Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USAUniv Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Jamieson, Beth D.
Tontonoz, Peter
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h-index: 0
机构:Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
机构:Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Bensinger, Steven J.
Bradley, Michelle N.
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Bradley, Michelle N.
Joseph, Sean B.
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Joseph, Sean B.
Zelcer, Noam
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Zelcer, Noam
Janssen, Edith M.
论文数: 0引用数: 0
h-index: 0
机构:
La Jolla Inst Allergy & Immunol, La Jolla, CA 92037 USAUniv Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Janssen, Edith M.
Hausner, Mary Ann
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USAUniv Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Hausner, Mary Ann
Shih, Roger
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USAUniv Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Shih, Roger
Parks, John S.
论文数: 0引用数: 0
h-index: 0
机构:
Wake Forest Univ, Sch Med, Dept Pathol, Winston Salem, NC 27157 USAUniv Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Parks, John S.
Edwards, Peter A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90049 USAUniv Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Edwards, Peter A.
Jamieson, Beth D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USAUniv Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA
Jamieson, Beth D.
Tontonoz, Peter
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, Los Angeles, CA 90049 USA