Metabolic reprogramming and metabolic dependency in T cells

被引:149
作者
Wang, Ruoning [1 ]
Green, Douglas R. [1 ]
机构
[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
关键词
metabolism; T lymphocytes; T-cell activation; MONOCARBOXYLATE TRANSPORTER MCT1; INTRACELLULAR GLUTATHIONE LEVELS; ENDOGENOUS NITRIC-OXIDE; GLUTAMINE-METABOLISM; L-ASPARAGINASE; IMMUNE-SYSTEM; LACTIC-ACID; AMINO-ACID; INDOLEAMINE 2,3-DIOXYGENASE; DENDRITIC CELLS;
D O I
10.1111/j.1600-065X.2012.01155.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Upon activation, quiescent naive T cells undergo a growth phase followed by massive clonal expansion and differentiation that are essential for appropriate immune defense and regulation. Accumulation of cell biomass during the initial growth and rapid proliferation during the expansion phase is associated with dramatically increased bioenergetic and biosynthetic demands. This not only requires a metabolic rewiring during the transition between resting and activation but also addicts active T cells to certain metabolic pathways in ways that naive and memory T cells are not. We consider such addiction in terms of the biological effects of deprivation of metabolic substrates or inhibition of specific pathways in T cells. In this review, we illustrate the relevant metabolic pathways revealed by recent metabolic flux analysis and discuss the consequences of metabolic intervention on specific metabolic pathways in T lymphocytes.
引用
收藏
页码:14 / 26
页数:13
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