Direct imaging of myocardial ischemia: A potential new paradigm in nuclear cardiovascular imaging

被引:21
作者
Jain, Diwakar [1 ]
He, Zuo-Xiang [2 ,3 ,4 ]
机构
[1] Drexel Univ, Coll Med, Nucl Cardiol Lab, Philadelphia, PA 19102 USA
[2] Peking Union Med Coll, Beijing 100021, Peoples R China
[3] Chinese Acad Med Sci, Cardiovasc Inst, Dept Nucl Med, Beijing 100037, Peoples R China
[4] Chinese Acad Med Sci, Fu Wai Hosp, Dept Nucl Med, Beijing 100037, Peoples R China
关键词
coronary artery disease; fluorine 18-labeled deoxyglucose; myocardial ischemia; iodine-123-beta-methyl-p-iodophenyl-pentadecanoic acid (I-123-BMIPP);
D O I
10.1016/j.nuclcard.2008.07.004
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Myocardial perfusion imaging has been in clinical use for over 30 years, serving as an effective, reliable, and relatively simple too] for diagnosis, risk stratification, and long-term follow-up of patients with suspected or known coronary artery disease. However, a unique strength of nuclear imaging is its ability to provide tools for imaging biochemical and metabolic processes and receptor and transporter functions at molecular and cellular levels in intact organisms under a wide variety of physiologic conditions. Despite their high resolution and technical sophistication, other imaging modalities currently do not have this capability. Metabolic imaging techniques using radiolabeled free fatty acid and glucose analogs provide a unique ability to image myocardial ischemia directly in patients with known or suspected coronary artery disease. These techniques can potentially overcome some of the limitations of currently used stress-rest perfusion imaging and also provide a unique opportunity to detect and image an episode of ischemia in the preceding hours even in the absence of other markers of ongoing myocardial ischemia. We describe recent studies using fluorine 18-labeled deoxyglucose and iodine 123 beta-methyl-p-iodophenyl-pentadecanoic acid for imaging myocardial ischemia.
引用
收藏
页码:617 / 630
页数:14
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