In vitro development of neural progenitor cells from human embryos

被引：4

作者：

Poltavtseva, RA

Rzhaninova, AA

Revishchin, AV

Aleksandrova, MA

Korochkin, LI

Repin, VS

Sukhikh, GT

机构：

[1] Russian Acad Sci, Inst Med Biol, Moscow, Russia

[2] Russian Acad Sci, Inst Gene Biol, Moscow, Russia

[3] Russian Acad Sci, NK Koltsov Dev Biol Inst, Moscow, Russia

[4] AN Severtsov Inst Ecol & Evolut Problems, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 132卷 / 03期

关键词：

neural stem/progenitor cells in human brain; tissue culture; development; differentiation;

D O I：

10.1023/A:1013170701936

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Behavior of stem/progenitor cells from the brain of human embryos during in vitro culturing was studied. Cultured cells from human embryonic brain developed and formed neurospheres heterogeneous by their cell composition. In a serum-containing medium some cells underwent differentiation by the neuronal pathway, while others remained in the stem state.

引用

收藏

页码：861 / 863

页数：3

相关论文

共 14 条

[1] AUTORADIOGRAPHIC AND HISTOLOGICAL STUDIES OF POSTNATAL NEUROGENESIS .I. A LONGITUDINAL INVESTIGATION OF KINETICS MIGRATION AND TRANSFORMATION OF CELLS INCORPORATING TRITIATED THYMIDINE IN NEONATE RATS WITH SPECIAL REFERENCE TO POSTNATAL NEUROGENESIS IN SOME BRAIN REGIONS [J].

ALTMAN, J ;

DAS, GD .

JOURNAL OF COMPARATIVE NEUROLOGY, 1966, 126 (03) :337-&

[2] AUTORADIOGRAPHIC AND HISTOLOGICAL EVIDENCE OF POSTNATAL HIPPOCAMPAL NEUROGENESIS IN RATS [J].

ALTMAN, J ;

DAS, GD .

JOURNAL OF COMPARATIVE NEUROLOGY, 1965, 124 (03) :319-&

[3] Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease [J].

Armstrong, RJE ;

Watts, C ;

Svendsen, CN ;

Dunnett, SB ;

Rosser, AE .

CELL TRANSPLANTATION, 2000, 9 (01) :55-64

[4]

CAGE FH, 2000, SCIENCE, V287, P1433

[5] In vitro expansion of a multipotent population of human neural progenitor cells [J].

Carpenter, MK ;

Cui, X ;

Hu, ZY ;

Jackson, J ;

Sherman, S ;

Seiger, Å ;

Wahlberg, LU .

EXPERIMENTAL NEUROLOGY, 1999, 158 (02) :265-278

[6] Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes [J].

Flax, JD ;

Aurora, S ;

Yang, CH ;

Simonin, C ;

Wills, AM ;

Billinghurst, LL ;

Jendoubi, M ;

Sidman, RL ;

Wolfe, JH ;

Kim, SU ;

Snyder, EY .

NATURE BIOTECHNOLOGY, 1998, 16 (11) :1033-1039

[7] PROLIFERATING SUBVENTRICULAR ZONE CELLS IN THE ADULT MAMMALIAN FOREBRAIN CAN DIFFERENTIATE INTO NEURONS AND GLIA [J].

LOIS, C ;

ALVAREZBUYLLA, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (05) :2074-2077

[8] Progenitor cell biology -: Implications for neural regeneration [J].

Mehler, MF ;

Kessler, JA .

ARCHIVES OF NEUROLOGY, 1999, 56 (07) :780-784

[9] Transplantation of neural stem cells: Cellular & gene therapy for hypoxic-ischemic brain injury [J].

Park, KI .

YONSEI MEDICAL JOURNAL, 2000, 41 (06) :825-835

[10] Genetically perpetuated human neural stem cells engraft and differentiate into the adult mammalian brain [J].

Rubio, FJ ;

Bueno, C ;

Villa, A ;

Navarro, B ;

Martínez-Serrano, A .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2000, 16 (01) :1-13