Hepatitis B virus: from immunobiology to immunotherapy

被引：22

作者：

Grimm, Daniel ^{[1
]}

Heeg, Maximilian ^{[1
]}

Thimme, Robert ^{[1
]}

机构：

[1] Univ Freiburg, Dept Med 2, D-79106 Freiburg, Germany

来源：

CLINICAL SCIENCE | 2013年 / 124卷 / 1-2期

关键词：

hepatitis B virus (HBV); immunity; immunobiology; infection; liver disease; T-CELL RESPONSES; ADAPTIVE IMMUNE-RESPONSES; LAMIVUDINE TREATMENT; VIRAL PERSISTENCE; X PROTEIN; INFECTION; EXPRESSION; INNATE; ACTIVATION; REPLICATION;

D O I：

10.1042/CS20120169

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Owing to the major limitations of current antiviral therapies in HBV (hepatitis B virus) infection, there is a strong need for novel therapeutic approaches to this major health burden. Stimulation of the host's innate and adaptive immune responses in a way that results in the resolution of viral infection is a promising approach. A better understanding of the virus-host interaction in acute and chronic HBV infection revealed several possible novel targets for antiviral immunotherapy. In the present review, we will discuss the current state of the art in HBV immunology and illustrate how control of infection could be achieved by immunotherapeutic interventions.

引用

页码：77 / 85

页数：9

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