Global implementation of genomic medicine: We are not alone

被引：131

作者：

Manolio, Teri A. ^{[1
]}

Abramowicz, Marc ^{[2
]}

Al-Mulla, Fahd ^{[3
]}

Anderson, Warwick ^{[4
]}

Balling, Rudi ^{[5
]}

Berger, Adam C. ^{[6
]}

Bleyl, Steven ^{[7
]}

Chakravarti, Aravinda ^{[8
]}

Chantratita, Wasun ^{[9
]}

Chisholm, Rex L. ^{[10
]}

Dissanayake, Vajira H. W. ^{[11
]}

Dunn, Michael ^{[12
]}

Dzau, Victor J. ^{[13
]}

Han, Bok-Ghee ^{[14
]}

Hubbard, Tim ^{[15
]}

Kolbe, Anne ^{[16
]}

Korf, Bruce ^{[17
]}

Kubo, Michiaki ^{[18
]}

Lasko, Paul ^{[19
,20
]}

Leego, Erkki ^{[21
]}

Mahasirimongkol, Surakameth ^{[22
]}

Majumdar, Partha P. ^{[23
,24
]}

Matthijs, Gert ^{[25
]}

McLeod, Howard L. ^{[26
]}

Metspalu, Andres ^{[21
]}

Meulien, Pierre ^{[27
]}

Miyano, Satoru ^{[28
]}

Naparstek, Yaakov ^{[29
]}

O'Rourke, P. Pearl ^{[30
]}

Patrinos, George P. ^{[31
]}

Rehm, Heidi L. ^{[32
]}

Relling, Mary V. ^{[33
]}

Rennert, Gad ^{[34
]}

Rodriguez, Laura Lyman ^{[1
]}

Roden, Dan M. ^{[35
]}

Shuldiner, Alan R. ^{[36
]}

Sinha, Sukdeb ^{[37
]}

Tan, Patrick ^{[38
]}

Ulfendahl, Mats ^{[39
]}

Ward, Robyn ^{[40
]}

Williams, Marc S. ^{[41
]}

Wong, John E. L. ^{[42
]}

Green, Eric D. ^{[1
]}

Ginsburg, Geoffrey S. ^{[43
]}

机构：

[1] NHGRI, NIH, Bethesda, MD 20892 USA

[2] Univ Libre Bruxelles, B-1070 Brussels, Belgium

[3] Kuwait Univ, Genatak Global Med Clin, Kuwait 46300, Kuwait

[4] Nat Hlth & Med Res Council, Canberra, ACT 2601, Australia

[5] Univ Luxembourg, Luxembourg Ctr Syst Biomed, L-4362 Esch Sur Alzette, Luxembourg

[6] Inst Med, Board Hlth Sci Policy, Washington, DC 20001 USA

[7] Intermt Healthcare, Salt Lake City, UT 84111 USA

[8] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

[9] Mahidol Univ, Ramathibodi Hosp, Bangkok 10400, Thailand

[10] Northwestern Univ Feinberg, Sch Med, Ctr Genet Med, Chicago, IL 60611 USA

[11] Univ Colombo, Fac Med, Human Genet Unit, Colombo 00800, Sri Lanka

[12] Wellcome Trust Res Labs, Genet & Mol Sci, London NW1 2BE, England

[13] Nat Acad Med, Washington, DC 20001 USA

[14] Korea Natl Inst Hlth, Ctr Genome Sci, Chungcheongbuk Do 363951, South Korea

[15] Kings Coll London, London SE1 9RT & Genom England, Dept Med & Mol Genet, London EC1M 6BQ, England

[16] Natl Hlth Comm, Auckland 1050, New Zealand

[17] Univ Alabama Birmingham, Ctr Genom Sci, Birmingham, AL 35294 USA

[18] RIKEN, Ctr Integrat Med Sci IMS, Yokohama, Kanagawa 2300045, Japan

[19] Canadian Inst Hlth Res, Inst Genet, Montreal, PQ H3A 0G4, Canada

[20] McGill Univ, Montreal, PQ H3A 0G4, Canada

[21] Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia

[22] Minist Publ Hlth, Dept Med Sci, Nonthaburi 11000, Thailand

[23] Nat Inst Biomed Genom, Kalyani 741251, W Bengal, India

[24] Indian Stat Inst, Kalyani 741251, W Bengal, India

[25] Univ Leuven, KU Leuven, Ctr Human Genet, B-3000 Leuven, Belgium

[26] Mofitt Canc Ctr, DeBartolo Family Personalized Med Inst, Tampa, FL 33612 USA

[27] Genome Canada, Ottawa, ON K2P 1P1, Canada

[28] Univ Tokyo, Inst Med Sci, Tokyo 1088639, Japan

[29] Hadassah Hebrew Univ Hosp, Res & Acad Affairs, IL-91120 Jerusalem, Israel

[30] Partners HealthCare, Off Human Res Affairs, Boston, MA 02199 USA

[31] Univ Patras, Sch Hlth Sci, Dept Pharm, Patras 26504, Greece

[32] Partners Healthcare Syst, Mol Med Lab, Boston, MA 02139 USA

[33] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

[34] Clalit Natl Personalized Med Program, Carmel Med Ctr, Dept Community Med & Epidemiol, IL-34362 Haifa, Israel

[35] Vanderbilt Univ, Sch Med, Nashville, TN 37232 USA

[36] Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA

[37] Minist Sci & Technol Govt, Dept Biotechnol, New Delhi 110003, India

[38] Duke Natl Univ Singapore, Grad Sch Med, Singapore 169857, Singapore

[39] Swedish Res Council, SE-10138 Stockholm, Sweden

[40] Univ Queensland, St Lucia, Qld 4067, Australia

[41] Genom Med Inst, Geisinger Hlth Syst, Danville, PA 18510 USA

[42] Natl Univ Singapore, Singapore 119228, Singapore

[43] Duke Univ, Ctr Appl Genom & Precis Med, Durham, NC 27710 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2015年 / 7卷 / 290期

关键词：

ECONOMIC-EVALUATION; PHARMACOGENOMICS; RECONSTRUCTION; OPPORTUNITIES; CHALLENGES; DATABASE; SOCIETY; SCIENCE; PROJECT; TIME;

D O I：

10.1126/scitranslmed.aab0194

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Around the world, innovative genomic-medicine programs capitalize on singular capabilities arising from local health care systems, cultural or political milieus, and unusual selected risk alleles or disease burdens. Such individual efforts might benefit from the sharing of approaches and lessons learned in other locales. The U.S. National Human Genome Research Institute and the National Academy of Medicine recently brought together 25 of these groups to compare projects, to examine the current state of implementation and desired near-term capabilities, and to identify opportunities for collaboration that promote the responsible practice of genomic medicine. Efforts to coalesce these groups around concrete but compelling signature projects should accelerate the responsible implementation of genomic medicine in efforts to improve clinical care worldwide.

引用

页数：8

共 44 条

[1]

[Anonymous], 1988, LANCET, V2, P349

[2]

[Anonymous], 2009, 1071 HL SEL COMM SCI, P104

[3]

Immunodeficiency at the Start of Combination Antiretroviral Therapy in Low-, Middle-, and High-Income Countries [J].

Avila, Dorita ;

Althoff, Keri N. ;

Mugglin, Catrina ;

Wools-Kaloustian, Kara ;

Koller, Manuel ;

Dabis, Franois ;

Nash, Denis ;

Gsponer, Thomas ;

Sungkanuparph, Somnuek ;

McGowan, Catherine ;

May, Margaret ;

Cooper, David ;

Chimbetete, Cleophas ;

Wolff, Marcelo ;

Collier, Ann ;

McManus, Hamish ;

Davies, Mary-Ann ;

Costagliola, Dominique ;

Crabtree-Ramirez, Brenda ;

Chaiwarith, Romanee ;

Cescon, Angela ;

Cornell, Morna ;

Diero, Lameck ;

Phanuphak, Praphan ;

Sawadogo, Adrien ;

Ehmer, Jochen ;

Eholie, Serge P. ;

Li, Patrick C. K. ;

Fox, Matthew P. ;

Gandhi, Neel R. ;

Gonzalez, Elsa ;

Lee, Christopher K. C. ;

Hoffmann, Christopher J. ;

Kambugu, Andrew ;

Keiser, Olivia ;

Ditangco, Rossana ;

Prozesky, Hans ;

Lampe, Fiona ;

Kumarasamy, Nagalingeswaran ;

Kitahata, Mari ;

Lugina, Emmanuel ;

Lyamuya, Rita ;

Vonthanak, Saphonn ;

Fink, Valeria ;

Monforte, Antonella d'Arminio ;

Luz, Paula Mendes ;

Chen, Yi-Ming A. ;

Minga, Albert ;

Casabona, Jordi ;

Mwango, Albert .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2014, 65 (01) :E8-E16

[4]

Prevention of neural-tube defects with folic acid in China [J].

Berry, RJ ;

Li, Z ;

Erickson, JD ;

Li, S ;

Moore, CA ;

Wang, H ;

Mulinare, J ;

Zhao, P ;

Wong, LYC ;

Gindler, J ;

Hong, SX ;

Correa, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (20) :1485-1490

[5]

Pharmacogenomics: Current State-of-the-Art [J].

Carr, Daniel F. ;

Alfirevic, Ana ;

Pirmohamed, Munir .

GENES, 2014, 5 (02) :430-443

[6]

Open science versus commercialization: a modern research conflict? [J].

Caulfield, Timothy ;

Harmon, Shawn H. E. ;

Joly, Yann .

GENOME MEDICINE, 2012, 4

[7]

Bridging genomics research between developed and developing countries: the Genomic Medicine Alliance [J].

Cooper, David N. ;

Brand, Angela ;

Dolzan, Vita ;

Fortina, Paolo ;

Innocenti, Federico ;

Lee, Ming Ta Michael ;

Macek, Milan, Jr. ;

Al-Mulla, Fahd ;

Prainsack, Barbara ;

Squassina, Alessio ;

Vayena, Effy ;

Vozikis, Athanassios ;

Williams, Marc S. ;

Patrinos, George P. .

PERSONALIZED MEDICINE, 2014, 11 (07) :615-623

[8]

Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore [J].

Dong, Di ;

Sung, Cynthia ;

Finkelstein, Eric Andrew .

NEUROLOGY, 2012, 79 (12) :1259-1267

[9]

Evidence Generating Medicine Redefining the Research-Practice Relationship to Complete the Evidence Cycle [J].

Embi, Peter J. ;

Payne, Philip R. O. .

MEDICAL CARE, 2013, 51 (08) :S87-S91

[10]

Use of continuous quality improvement to increase use of process measures in patients undergoing coronary artery bypass graft surgery - A randomized controlled trial [J].

Ferguson, TB ;

Peterson, ED ;

Coombs, LP ;

Eiken, MC ;

Carey, ML ;

Grover, FL ;

DeLong, ER .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (01) :49-56

← 1 2 3 4 5 →