Environmentally friendly synthesis of biaryls: Suzuki reaction of aryl bromides in water at low catalyst loadings

被引：48

作者：

Jiang, N ^{[1
]}

Ragauskas, AJ ^{[1
]}

机构：

[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 02期

关键词：

Suzuki reaction; biaryls; turnover number; Green chemistry;

D O I：

10.1016/j.tetlet.2005.10.158

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pd(DPPF)Cl(2) is shown to be an extremely active catalyst for the Suzuki reaction of aryl bromides in water. This green procedure provides biaryls in excellent yields and high turnover numbers (TONs) (TONs up to 870,000 for the reaction of 1-bromo4-nitrobenzene and phenylboronic acid). A small amount of PEG-2000 also allows the recycling of the palladium catalyst for three times without any significant loss of catalytic activity. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：197 / 200

页数：4

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